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Barietin, a snake venom vascular endothelial growth factor from puff adder Bitis arietans venom, increases the heart rate with minor effect on blood pressure in rats

  Barietin, a snake venom vascular endothelial growth factor from puff adder Bitis arietans venom, increases the heart rate with minor effect on blood pressure in rats ABSTRACT Snake venom vascular endothelial growth factors (svVEGFs) are homodimeric proteins comprising two equal subunits bound by two intermolecular disulfide bonds. The main biological effects of svVEGFs are local vasodilatation, increasing of vascular permeability, and hypotension. Barietin, a svVEGF purified from the venom of puff adder Bitis arietans , differs from other representatives of this toxin family by its shortened C-terminal amino acid sequence. No data about barietin effects on hemodynamics are available. Studying those in rats we found that barietin at a dose of 1 mg/kg significantly increased heart rate, exerting only a minor influence on blood pressure. In this respect, it differs from other svVEGFs having a significant effect on blood pressure. We aimed to find the barietin active fragment which m...

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Tracking the hidden trade of non-native pet amphibians in the United States

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Stronger El Niños reduce tropical forest arthropod diversity and function

Machine learning approaches to assess microendemicity and conservation risk in cave-dwelling arachnofauna

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Declining freshwater habitats in Greenland may shift diets of the ubiquitous wolf spider Pardosa glacialis

The spider fauna of Danish coastal dune habitats revisited after 25 years: evidence of faunistic impoverishment

Spiders (Arachnida: Araneae) of a wildlife and cattle savanna ranch in South-Western Zimbabwe

Surveys of Aphonopelma hentzi in Missouri: Conservation Efforts through Population, Genetics, and Habitat Studies

The role of social media groups on illegal wildlife trade in four Mexican states: A year-long assessment

Comparison of desiccation resistance in the litter-dwelling scorpion Tityus pusillus Pocock, 1893 (Scorpiones: Buthidae) from dry and wet tropical forests