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Could venom-derived therapeutics resolve treatment resistance in refractory EAC?

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  Could venom-derived therapeutics resolve treatment resistance in refractory EAC? Abstract The incidence of esophageal adenocarcinoma is rising in Western countries. Despite advances in chemotherapy and immunotherapy, the prognosis remains poor, with an overall 5-year survival rate below 15%. A major challenge is the cancer’s poor and often unpredictable response to current treatments. Animal venoms represent a promising yet underexplored source of therapeutic agents, offering millions of structurally diverse and highly potent bioactive peptides that can modulate a wide array of molecular targets. However, only a small fraction of these peptides has been pharmacologically characterized. This review presents the therapeutic potential of venom-derived peptides in cancer treatment, summarizes the role of ion channels in esophageal adenocarcinoma (EAC), and discusses peptides targeting ion channels that may offer new opportunities for future EAC treatment. Freuville L, Matthys C, Gill...

New data on spiders (Arachnida, Araneae) of the Arabian Peninsula and the Levant, with new species and records

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First record of a crab spider Xysticus crispabilis Song & Gao, 1996 (Araneae: Thomisidae) from Japan with the first description of a female

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Soil Preference and Burrow Characteristics of Two Theraphosidae Species in Penang Island, Malaysia

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Indian lone commercial antivenom against Indian red scorpion venom demonstrates limited immunorecognition and partial neutralisation of enzymatic, pharmacological, and some toxic effects of Heterometrus bengalensis (Indian black scorpion) venom proteins in vitro and in vivo

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The first known troglomorphic, eyeless spider wasp (Hymenoptera: Pompilidae): Troglopompilus miracaecatus gen. et sp. nov. from the Nullarbor Caves, Western Australia

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Expanding the horizon: Discovery of two new spider species of the Pholcus phungiformes species group (Araneae, Pholcidae) from Inner Mongolia, China, with a new western record for the group

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A chelicera-bearing arthropod reveals the Cambrian origin of chelicerates

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New species and records of Otiothops MacLeay, 1839 (Araneae, Palpimanidae) from caves of the Carajás region, state of Pará, Brazil

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Biochemical characterisation and substrate-specific proteolytic diversity of venom metalloproteinases in African puff adders

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Insights Into Spatial Orientation and Cognition in Tarantulas (Araneae: Theraphosidae) Under Natural Conditions, With Notes on Possible Ontogenetic Niche Shifts

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Diversity and antibiotic resistance profiles of bacteria isolated from the oral cavity of captive snakes

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Effect of web inclination on debris-induced damage in Leucauge venusta webs (Araneae: Tetragnathidae)

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Desiccation resistance of the spider Sicarius thomisoides (Walckenaer, 1847) (Araneae: Sicariidae) to different temperatures

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Efficacy of neem oil (Azadirachta indica) as an antiparasitic treatment for scorpions (Androctonus bicolor) and its impact on venom production

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Can Scorpion Venom Peptides Be Safely Used in Cardiovascular Therapy: A Systematic Review

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First record of Tropicosa thorelli (Araneae: Lycosidae) attacking the dragonfly Rhionaeschna marchali (Odonata: Aeshnidae)

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Social and colonial spiders as model systems for host-symbiont interactions at different levels of organization

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Ghost sighting: first Southeast Asian record of the ghost spider family Anyphaenidae, describing a new Rathalos species from Java, Indonesia

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Ovophis tonkinensis envenoming presenting with severe isolated thrombocytopenia and local necrosis: A case report

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Passive transponder implantation in Theraphosidae: A tool for traceability and conservation

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Rhysida longipes (Scolopendromorpha: Scolopendridae), an unusual prey of Physocyclus globosus (Araneae: Pholcidae)

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