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Ziyuglycoside I Attenuates Deinagkistrodon acutus Venom–Induced Injury in Renal Tubular Epithelial Cells by Modulating PAR1–NLRP3–IL-1β Signaling

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  Ziyuglycoside I Attenuates Deinagkistrodon acutus Venom–Induced Injury in Renal Tubular Epithelial Cells by Modulating PAR1–NLRP3–IL-1β Signaling Abstract Introduction Sanguisorba officinalis L. ( Di Yu ) has traditionally been used for snakebite treatment. Ziyuglycoside I, a major bioactive constituent of Di Yu , exhibits anti-inflammatory activity, but its role in snake venom-associated renal injury remains unclear. This study aimed to investigate its potential protective effects against Deinagkistrodon acutus venom (DAV)-induced renal tubular epithelial cell injury in vitro. Methods HK-2 cells were exposed to DAV to establish an in vitro renal tubular epithelial injury model. Cellular metabolic activity and intracellular ATP levels were assessed using Cell Counting Kit-8 and CellTiter-Glo assays, respectively. DAV-induced molecular alterations were examined by transcriptomic sequencing, bioinformatic analysis, western blotting, and qRT-PCR. PAR1 knockdown and pharmacological...

Re-examination of the type materials of seven species of Plexippina (Araneae, Salticidae) from China

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Admission Point-of-Care D-Dimer for Identifying Haemostatic Envenomation After Snakebite: A Prospective Observational Study

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The impact of Centruroides tecomanus scorpion venom on cardiac function in rats during early envenomation

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Climatic and density-dependent drivers of population dynamics in a hazardous urban scorpion species over seven years

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Catalogue of the scorpions of Paraguay, with an illustrated key and biogeographical assessment (Arachnida: Scorpiones: Ananteridae, Bothriuridae, Buthidae)

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Joining the dark side: waterfall spiders in subterranean habitats, with the description of a new genus and two new species from Brazil (Araneae: Trechaleidae)

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A new species of Raveniola Zonstein, 1987 (Araneae, Nemesiidae) from Jinggangshan National Nature Reserve, Jiangxi Province, China

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Seasonal Variation in Whole-Body Elemental Concentrations and Excreta Production of a Riparian Orb-Weaving Spider (Larinioides cornutus)

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First documented cases of invertebrate predation by greater grisons (Galictis vittata)

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Two new spider species of the genus Melpomene O. Pickard-Cambridge, 1898, from Colombia and Panama with complementary description of M. panamana (Petrunkevitch, 1925) (Araneae: Agelenidae)

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Modelling the potential distribution and conservation scenarios for the troglobitic spider Pinelema elinae Brescovit, Gallão & Cizauskas, 2023 (Telemidae) in the Neotropics: palaeoclimatic evidence and current threats

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Hemostasis-Modulating Proteins from Indian Elapid and Viper Snake Venom: Mechanistic Insights and Therapeutic Opportunities

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In Memoriam: Giraldo Alayón García

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The first genus with four sac-like structures in the vulva in the cobweb spider subfamily Theridiinae Sundevall, 1833 (Araneae: Theridiidae)

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A new species of Urupelma Kaderka et al. 2023 from Peru (Araneae, Theraphosidae, Theraphosinae), and a new proposal of homologous keels

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