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Role of snake venom proteases and tissue factor in venom induced hemostatic disorders and local hemorrhage in mice

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  Role of snake venom proteases and tissue factor in venom induced hemostatic disorders and local hemorrhage in mice Abstract Bothrops jararaca venom (BjV) induces hemostatic and inflammatory manifestations. Tissue factor (TF) is essential for hemostasis, but aberrant TF expression can cause coagulopathy. We determined the effect of inhibition of BjV serine proteases and metalloproteinases, as well as host TF, on the systemic coagulopathy and local hemorrhage in envenomed mice. Venom serine proteases induced hypofibrinogenemia whereas venom metalloproteinases induced hemorrhage. TF did not contribute to venom-induced coagulopathy, but played a protective role in venom-induced bleeding in mice. Sachetto, A. T., Mackman, N., & Santoro, M. L. (2026). Role of snake venom proteases and tissue factor in venom induced hemostatic disorders and local hemorrhage in mice. Toxicon , 109299. https://doi.org/10.1016/j.toxicon.2026.109299

Enzymatic and non-enzymatic proteins from Bothrops snake venoms, their anticancer activity, and translational challenges in oncovenomics: A review

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Elevational patterns and assembly processes of centipede and spider diversity on Changbai Mountain, China

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Morphological variation in populations of Pinelema elinae Brescovit, Gallão & Cizauskas, 2023 (Araneae, Telemidae): a morphometric analysis with natural history notes

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Genomic signatures associated with convergent funnel‐web building behavior in spiders

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New taxonomic and faunistic data on spiders (Arachnida: Araneae) from Iraqi Kurdistan, with an updated regional checklist

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Three new species of the genus Pseudopoda Jäger, 2000 (Araneae, Sparassidae, Heteropodinae) from China

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New data on Wangaraneus Mi, Wang & Li, 2024 (Araneae, Araneidae), with descriptions of two new species from Xizang, China

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The largest fossil of the segmented spider Parvithele muelleri Wunderlich, 2017 (Mesothelae: Parvithelidae) from Cretaceous Burmese amber

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The chromosome-level genome of Mesobuthus martensii provides insights into its evolution and the diversity of venom peptides

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What a Long Strange Trip It's Been: Miocene Salinian Block Migration and the Biogeography of Megahexura Spiders

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Reference genome of the Californian trapdoor spider Aptostichus stephencolberti Bond 2008 (Araneae: Mygalomorphae: Euctenizidae)

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Expression and function of two olfactory-related genes in response to methyl salicylate in the wolf spider Pardosa pseudoannulata (Araneae: Lycosidae)

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Scorpion Peptides in Antiviral Drug Discovery: An In-depth Review

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A new species of Ixchela Huber (Araneae: Pholcidae) from Honduras with updated taxonomic keys, and first record of Physocyclus globosus (Taczanowski)

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A pseudoscorpion clinging to a cave salamander: phoresy or failed predation?

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