Taxonomy Takes Time: Shortcuts to Synonymy

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  Taxonomy Takes Time: Shortcuts to Synonymy Abstract Taxonomy is the foundation of biology, providing the currency (species) for biological studies and the handle (epithet) to refer to them. The task at hand is urgent: a race against extinction as most species remain undescribed and expertise declines. In response, various ‘rapid taxonomy’ approaches aim to hasten descriptions. Good examples exist that genuinely accelerate the growth of taxonomic knowledge, but shortcuts risk errors that may take more time to resolve than the original work took to produce. Authors must consider (1) the total time budget, including subsequent revisions necessitated by inadequate taxonomy; (2) the taxonomic literature on regional and widespread taxa; and (3) illustration quality as a critical and enduring component of species description. Reviewers and editors must also ensure minimum standards. I discuss a recent example where shortcuts, instead of accelerating taxonomy, merely borrowed time. Anelo...

Anticancer potentiality of Hottentotta saulcyi scorpion curd venom against breast cancer: an in vitro and in vivo study

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Anticancer potentiality of Hottentotta saulcyi scorpion curd venom against breast cancer: an in vitro and in vivo study

Abstract

Scorpion venom may include pharmacological substances that have the potential to provide benefits. Multiple scientific investigations have shown that particular scorpion venoms induce apoptosis and inhibit the development of cancerous cells. The present study investigated the potential anticancer properties of the crude venom derived from Hottentotta saulcyi (H. saulcyi) on both in vivo mice models and in vitro breast carcinoma cells. The venom of scorpions belonging to the species H. saulcyi was obtained with the application of electrical stimulation at voltages of 8 and 10 V. The determination of the Average Lethal Dose 50 (LD50) was conducted. The present work assessed the in vitro cytotoxicity and morphological characteristics of H. saulcyi venom using fluorescence microscopy, MTT assay, and flow cytometry assessment. Additionally, research was performed to assess the cytotoxic effects in vivo on a mouse model with breast cancer. The examination of MCF-7 cells treated with scorpion venom at a microscopic level revealed the existence of cells undergoing apoptosis. The venom of H. saulcyi has anticancer properties, as shown by the observation that MCF-7 cells had a 62.12% apoptotic rate when exposed to a dose of 1.47 mg/L. Based on the results obtained, it can be shown that the viability of MCF-7 cells has exhibited a substantial reduction (P < 0.01). Furthermore, the findings indicated that the venom of H. saulcyi resulted in a significant increase in the synthesis of TNF-α, IL-6, IL-10, TGF-β, and caspase (P < 0.05). The treatment groups administered with H. saulcyi venom exhibited a significant augmentation in the expression of proapoptotic genes compared to the control group of healthy individuals. The transcription of the BCL2 gene exhibited a statistically significant increase in the healthy control group compared to both the healthy venom-treated group (P < 0.05) and the malignant venom-treated group (P < 0.01). The crude venom of H. saulcyi has considerable promise in demonstrating anticancer properties. Further investigation may be warranted to explore the potential of using H. saulcyi crude venom as a medicinal platform for the prevention of breast cancer.

Nosouhian, M., Rastegari, A. A., Shahanipour, K., Ahadi, A. M., & Sajjadieh, M. S. (2024). Anticancer potentiality of Hottentotta saulcyi scorpion curd venom against breast cancer: An in vitro and in vivo study. Scientific Reports, 14(1), 1-19. https://doi.org/10.1038/s41598-024-75183-w