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Role of snake venom proteases and tissue factor in venom induced hemostatic disorders and local hemorrhage in mice

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  Role of snake venom proteases and tissue factor in venom induced hemostatic disorders and local hemorrhage in mice Abstract Bothrops jararaca venom (BjV) induces hemostatic and inflammatory manifestations. Tissue factor (TF) is essential for hemostasis, but aberrant TF expression can cause coagulopathy. We determined the effect of inhibition of BjV serine proteases and metalloproteinases, as well as host TF, on the systemic coagulopathy and local hemorrhage in envenomed mice. Venom serine proteases induced hypofibrinogenemia whereas venom metalloproteinases induced hemorrhage. TF did not contribute to venom-induced coagulopathy, but played a protective role in venom-induced bleeding in mice. Sachetto, A. T., Mackman, N., & Santoro, M. L. (2026). Role of snake venom proteases and tissue factor in venom induced hemostatic disorders and local hemorrhage in mice. Toxicon , 109299. https://doi.org/10.1016/j.toxicon.2026.109299

A new whip scorpion (Arachnida: Thelyphonida) with a phoretic mite (Acariformes: Trochometridiidae) from Mid-Cretaceous Kachin amber

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The story of a Tailless Whip Scorpion in Eastern Mediterranean: First report of Sarax ioanniticus (Kritscher, 1959) in Cyprus (Amblypygi: Charinidae)

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Phylogeny of the Neotropical Hypoctonine Whip-Scorpions (Thelyphonida, Thelyphonidae), with Descriptions of Two New Genera and Species

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Habitat of two threatened short-tailed whip-scorpions (Arachnida: Schizomida) in the tropical Andes of Northern South America

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A new specimen of whip scorpion (Arachnida; Thelyphonida) from the Crato Formation, Lower Cretaceous of Brazil

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Predation of a whip scorpion by a Pantropical Huntsman Spider

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The largest Palaeozoic whip scorpion and the smallest (Arachnida: Uropygi: Thelyphonida); a new species and a new ichnospecies from the Carboniferous of New England, USA

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First description of the male genitalia in a short-tailed whipscorpion (Arachnida: Schizomida), description of the female, and comments on pygidial glands and cuticular ultrastructure of Surazomus algodoal Ruiz & Valente, 2017

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