Scorpion Venom Peptides: From Structural Scaffolds to Therapeutic Applications—A Focus on Antioxidant Mechanisms and Translational Perspectives

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  Scorpion Venom Peptides: From Structural Scaffolds to Therapeutic Applications—A Focus on Antioxidant Mechanisms and Translational Perspectives Abstract Scorpion venom peptides, with their stable disulfide backbone, compact structural framework, and highly selective regulation of ion channels, have long been regarded as important molecular probes in neuropharmacology. However, recent studies have revealed their potential for regulating oxidative stress, inflammation, and neuroprotection, making them a new research frontier. In this article, we focus on scorpion venom peptides as drugs, constructing an integrated knowledge framework from structural classification to clinical translation. First, scorpion venom peptides are systematically classified based on cysteine arrangement patterns and three-dimensional folding topology, and their structure–activity relationships are summarized. Based on this, the molecular mechanisms by which scorpion venom peptides regulate ion channels are ...

New records of Segestria florentina from Germany with observations on somatic and genitalic differences in juveniles and adults compared to S. bavarica (Araneae: Segestriidae)

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New records of Segestria florentina from Germany with observations on somatic and genitalic differences in juveniles and adults compared to S. bavarica (Araneae: Segestriidae)

Abstract

New records of the large tube web spider Segestria florentina (Rossi, 1790) from Essen in North Rhine-Westphalia in Germany are presented. Genital characteristics of specimens from Germany are compared with those of the native Segestria bavarica C. L. Koch, 1843. For differentiation of juveniles of the two species, characteristics of the leg spination and opisthosomal colouration are described.

Lauterbach, S., & Imbusch, G. (2026). New records of Segestria florentina from Germany with observations on somatic and genitalic differences in juveniles and adults compared to S. bavarica (Araneae: Segestriidae). Arachnologische Mitteilungen / Arachnology Letters, 71, 14–22. https://doi.org/10.30963/aramit7104