Qualitative and Quantitative Proteomic Analysis of Venoms from Mexican Rattlesnakes

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  Qualitative and Quantitative Proteomic Analysis of Venoms from Mexican Rattlesnakes Abstract Despite the vast biodiversity of Mexican vipers, venom of endemic species has been barely studied. Here we analyzed the venom composition of three endemic species of rattlesnakes: Crotalus aquilus , C. triseriatus , and C. ravus . We used quantitative chromato-mass-spectrometry and compared venoms with C. molossus , a species commonly found in North America, in a comparative and phylogenetic framework. In total, we identified 165 proteins grouped in 19 main protein families, consistent with previous reports for viperid venoms. In C. aquilus and C. triseriatus , the most predominant protein-family type was Serine Proteases, and in C. triseriatus and C. molossus it was Snake Venom Metalloproteases. The Label-free quantification revealed a high proportion of Snake Venom Metalloproteases in C. aquilus , C. triseriatus , and C. molossus , reaching 28–47% of the total venom. In contrast, in ...

The Dose Makes the Cure: Harnessing the Therapeutic Potential of Peruvian Snake Venoms

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The Dose Makes the Cure: Harnessing the Therapeutic Potential of Peruvian Snake Venoms

Abstract

For decades, snake venom has been studied for its diverse array of biological properties. From the isolation of various biomolecules, it has been possible to obtain resources for the development of therapeutic tools for a wide variety of medical conditions. This work compiles findings from multiple studies conducted on the subject, focusing specifically on the biomolecules from the four genera of venomous snakes found in Peru—Bothrops, Crotalus, Lachesis, and Micrurus—to highlight their importance as resources for biotechnological research. It presents information on metalloproteases, disintegrins, phospholipases A2, L-amino acid oxidases, serine proteases, and other biomolecules isolated from different species of these genera, describing their characteristics and potential applications in the development of therapeutic tools to treat a wide range of ailments, such as microbial and viral infections, various types of pain, and cancer, among others. Lastly, it briefly outlines several suggestions for the conservation and protection of these species, in hopes of expressing gratitude toward the natural sources that provide these valuable resources.

Quispe Vidal, G. (2026). The Dose Makes the Cure: Harnessing the Therapeutic Potential of Peruvian Snake Venoms. Research Archive of Rising Scholars. Preprint. https://doi.org/10.58445/rars.3550