Role of snake venom proteases and tissue factor in venom induced hemostatic disorders and local hemorrhage in mice

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  Role of snake venom proteases and tissue factor in venom induced hemostatic disorders and local hemorrhage in mice Abstract Bothrops jararaca venom (BjV) induces hemostatic and inflammatory manifestations. Tissue factor (TF) is essential for hemostasis, but aberrant TF expression can cause coagulopathy. We determined the effect of inhibition of BjV serine proteases and metalloproteinases, as well as host TF, on the systemic coagulopathy and local hemorrhage in envenomed mice. Venom serine proteases induced hypofibrinogenemia whereas venom metalloproteinases induced hemorrhage. TF did not contribute to venom-induced coagulopathy, but played a protective role in venom-induced bleeding in mice. Sachetto, A. T., Mackman, N., & Santoro, M. L. (2026). Role of snake venom proteases and tissue factor in venom induced hemostatic disorders and local hemorrhage in mice. Toxicon , 109299. https://doi.org/10.1016/j.toxicon.2026.109299

DNA barcoding of scorpions from Kosovo, with the first record of Alpiscorpius dinaricus (Di Caporiacco) (Scorpiones: Euscorpiidae)

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DNA barcoding of scorpions from Kosovo, with the first record of Alpiscorpius dinaricus (Di Caporiacco) (Scorpiones: Euscorpiidae)

ABSTRACT

This study presents DNA barcoding data for Alpiscorpius dinaricus (Di Caporiacco) and Euscorpius hadzii Caporiacco. Barcode sequences were compared with publicly available reference data to support species identification, together with the evaluation of diagnostic morphological characters. Alpiscorpius dinaricus is recorded from Kosovo for the first time, representing a new national record and contributing to the knowledge of euscorpiid diversity in the region. Diagnostic illustrations of A. dinaricus are provided to facilitate reliable identification and to support future faunistic, taxonomic, and biogeographic studies. Euscorpius hadzii, previously known only from Prizren district, is now reported also from Bjeshkët e Nemuna Mountains (Western Kosovo).

Geci, D., Ibrahimi, H., Bilalli, A., Musliu, M., Strohmeier, T., Koblmüller, S., … Sherwood, D. (2026). DNA barcoding of scorpions from Kosovo, with the first record of Alpiscorpius dinaricus (Di Caporiacco) (Scorpiones: Euscorpiidae). Journal of Natural History, 60(21–24), 1243–1258. https://doi.org/10.1080/00222933.2026.2655404