The impact of Centruroides tecomanus scorpion venom on cardiac function in rats during early envenomation
The impact of Centruroides tecomanus scorpion venom on cardiac function in rats during early envenomation
The impact of Centruroides tecomanus scorpion venom on cardiac function in rats during early envenomation Abstract Scorpion envenomation is a medical emergency that can produce severe cardiovascular complications . Centruroides tecomanus , an endemic scorpion species from western Mexico, is medically relevant, although its early cardiac effects remain poorly characterized. This study evaluated the initial cardiotoxic effects of C. tecomanus venom in Wistar rats using serial electrocardiographic recordings, algorithm-based ECG signal processing, histopathology, and serum biochemical markers. Fourteen rats were allocated to control and venom-treated groups (n = 7 per group). The experimental group received an intraperitoneal sublethal dose equivalent to one-third of the LD 50 . One-minute ECG recordings obtained at 5-min intervals during the first hour were analyzed using an enhanced computational algorithm for noise reduction, R-peak detection, R–R interval analysis, and characte...
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