Snake venom toxins in cancer therapy: advances in targeted delivery and peptide design

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  Snake venom toxins in cancer therapy: advances in targeted delivery and peptide design Abstract Snake venom represents a potent biological arsenal of cytotoxic compounds. Venom proteins and peptides, including disintegrins, venomous enzymes, three-finger toxins, and serine proteases, have garnered attention as effective anticancer agents. Despite their efficacy at nano- or micromolar concentrations, non-standardized mixtures often limit their therapeutic utilization, necessitating fractionation to minimize side effects. This review examines the antitumor potential of snake venom and its constituent proteins and peptides through a literature search in NCBI PubMed. We highlight the antitumor efficacies of venom polypeptides by correlating them with IC 50 values across various cell lines, demonstrating micromolar cytotoxic concentrations. The review encompasses several key areas: whole venom antitumor efficacy, mechanisms of action of individual proteins and peptides, fractionation...

Scorpion fauna of urban Delhi, India

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Scorpion fauna of urban Delhi, India

Abstract

Delhi, one of the world’s most populous cities, hosts a diverse array of urban habitats amidst its limited green cover. Scorpions, distinguished by their venomous stings and ancient lineage, thrive in Delhi’s semi-arid climate. Despite their ecological significance, studies on scorpion diversity in urban environments remain scarce. This study aimed to address this gap by conducting the first systematic assessment of scorpion diversity in Delhi. Field surveys were conducted during both day and night to collect specimens, which were then identified using established taxonomic keys. Four scorpion species from two families were recorded, including Chersonesometrus fulvipes, Isometrus maculatus, Compsobuthus rugosulus, and Lychas cf. biharensis. The semi-arid climate of Delhi, within the Punjab plains biogeographic province, provides a conducive environment for scorpion species to inhabit. This study serves as a preliminary assessment of scorpion diversity in Delhi and underscores the need for further dedicated surveys to comprehensively understand their distribution and ecology in the region.

Barhadiya, G., Pandey, P., Sultana, A., Mohapatra, P. P., & Das, S. K. (2025). Scorpion fauna of urban Delhi, India. Records of the Zoological Survey of India, 125(1), 57–62. https://doi.org/10.26515/rzsi/v125/i1/2025/172690