First catalog of spiders of Egypt (Araneae)

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  First catalog of spiders of Egypt (Araneae) Abstract This study provides a comprehensive catalog of the spider fauna of Egypt, comprising 389 species assigned to 197 genera and 40 families. For each species, all published locality records are compiled and accompanied by complete bibliographic references. The dataset has been carefully reviewed and critically evaluated in light of the most recent taxonomic and faunistic information. Among the recorded species, 55 (14.13%) are currently known only from Egypt and are thus considered endemic. Based on the World Spider Catalog (2026), 28 species are treated as nomina dubia, 23 species lack confirmed records from Egypt, which is not correct, 10 have to be omitted from the Egyptian list and 8 are species inquirenda. Despite the relatively high number of documented species, the Egyptian araneofauna remains insufficiently explored. Given the country’s ecological diversity and biogeographical position, further research is expected to signi...

Venomics of the six-eyed sand spider, Sicarius rugosus (Araneae: Sicariidae), from the neotropical dry forest of Costa Rica

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Venomics of the six-eyed sand spider, Sicarius rugosus (Araneae: Sicariidae), from the neotropical dry forest of Costa Rica

Abstract

Background

Sicarius rugosus, the only member of the genus that inhabits Central America, is phylogenetically related to South American Sicarius spiders. These originated from a common ancestor with sister African species. Like Loxosceles, Sicarius exhibits venom phospholipase D activity due to a group of toxins known collectively as SicTox.

Methods

A gel-assisted, bottom-up, proteomic analysis was performed to characterize the venom composition of S. rugosus. Hyaluronidase activity was determined using zymography.

Results

We identified several SicTox sequences, all classified as β-clade paralogs and sharing unique peptides with proteins from S. patagonicus, S. peruensis, and other species. Enzymes such as metalloproteinases, including putative astacins, carboxypeptidases, and angiotensin-converting enzymes, were detected in the venom. We also identified probable serine proteinases and a toxin-processing peptidylglycine α-hydroxylating monooxygenase, which may participate in venom peptide maturation. The venom displays in vitro hyaluronidase activity. Some likely peptide toxins were also identified, including a sicaritoxin, which preferentially targets insects.

Conclusion

This represents the first proteomic study of the rare six-eyed sand spider, S. rugosus, from the dry forest of Costa Rica, confirming the presence of sequences similar to phospholipases D of other Sicarius and Loxosceles species, as well as venom neuropeptides and enzymes characteristic of the family Sicariidae, which may participate in tissue spreading and processing of other venom constituents.

Díaz, C., Bonilla, F., Fernández, J. et al. Venomics of the six-eyed sand spider, Sicarius rugosus (Araneae: Sicariidae), from the neotropical dry forest of Costa Rica. JoBAZ 87, 40 (2026). https://doi.org/10.1186/s41936-026-00579-1