Antitumor activity of scorpion venom-derived peptides: A meta-analysis of preclinical studies

Posted by
  Antitumor activity of scorpion venom-derived peptides: A meta-analysis of preclinical studies Abstract Despite advances in cancer therapeutics, there are still challenges in improving drug toxicity and selectivity. Peptides from various venous species have recently garnered attention for their biopharmaceutical potential, particularly in cancer. The present study aimed to conduct a meta-analysis of the antitumor activity of scorpion venom-derived peptides (SVDPs) previously reported in preclinical models. The bibliographic research included original and review articles written in English published from 2015 to 2026. Studies within the scope were retrieved from the EBSCO Discovery Service, PubMed, and WIPO databases. A total of 27 articles that met the inclusion and exclusion criteria were included in this research, and the collected data were synthesized through a meta-analysis. In the included in vitro and in vivo studies, the effect of SVDPs on breast/mammary gland, cervical,...

A hairy giant among dwarves: Trichopelma grande, a distinct new species of tarantula from Cuba (Araneae: Theraphosidae)

Posted by

 


A hairy giant among dwarves: Trichopelma grande, a distinct new species of tarantula from Cuba (Araneae: Theraphosidae)

ABSTRACT

Large size, tropical climate, topographic complexity, and millions of years of isolation have turned the Greater Antillean islands into natural laboratories of evolution. Several groups have experienced explosive diversification across these islands, leading to highly diverse and endemic biotas and species experiencing unique adaptations. Here we describe a new tarantula species from the Viñales area, a biodiversity hotspot in western Cuba. Despite being a middle-sized species with large projected setae on the legs, reminiscent of those in arboreal tarantulas, phylogenomic analysis, diagnostic morphological features, and trap-door retreat building behaviour identifies it as the largest known representative of Trichopelma, and the only one with such hirsute legs. We provide mitochondrial barcoding data and a database of ultraconserved elements loci of the holotype of this species, which will help to include it in future phylogenetic studies of Theraphosidae. Given its limited distribution range, and its apparent absence in natural history collections despite its distinct appearance, this species might be scarce, positioning it as a potential conservation concern.

Ortiz, D., & Fonseca, E. (2024). A hairy giant among dwarves: Trichopelma grande, a distinct new species of tarantula from Cuba (Araneae: Theraphosidae). Journal of Natural History, 58(45–48), 2189–2205. https://doi.org/10.1080/00222933.2024.2401921