Could venom-derived therapeutics resolve treatment resistance in refractory EAC?

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  Could venom-derived therapeutics resolve treatment resistance in refractory EAC? Abstract The incidence of esophageal adenocarcinoma is rising in Western countries. Despite advances in chemotherapy and immunotherapy, the prognosis remains poor, with an overall 5-year survival rate below 15%. A major challenge is the cancer’s poor and often unpredictable response to current treatments. Animal venoms represent a promising yet underexplored source of therapeutic agents, offering millions of structurally diverse and highly potent bioactive peptides that can modulate a wide array of molecular targets. However, only a small fraction of these peptides has been pharmacologically characterized. This review presents the therapeutic potential of venom-derived peptides in cancer treatment, summarizes the role of ion channels in esophageal adenocarcinoma (EAC), and discusses peptides targeting ion channels that may offer new opportunities for future EAC treatment. Freuville L, Matthys C, Gill...

First record of a crab spider Xysticus crispabilis Song & Gao, 1996 (Araneae: Thomisidae) from Japan with the first description of a female

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First record of a crab spider Xysticus crispabilis Song & Gao, 1996 (Araneae: Thomisidae) from Japan with the first description of a female

ABSTRACT

A crab spider species, Xysticus crispabilis Song & Gao, 1996 (Araneae: Thomisidae), originally described from Anhui, China based on a single male specimen, is newly recorded from Japan. This study represents the second specimen-based record of the species since its original description. Detailed redescriptions of genital morphology, coloration and markings of the male are provided based on fresh material. The previously unknown female is described for the first time. In addition, genital images of the holotype, DNA barcoding data, preliminary molecular phylogeny, and ecological notes are presented.
Suzuki, Y., & Lin, Y. (2026). First record of a crab spider Xysticus crispabilis Song & Gao, 1996 (Araneae: Thomisidae) from Japan with the first description of a female. Journal of Asia-Pacific Biodiversity. https://doi.org/10.1016/j.japb.2026.03.005