Sex Pheromones From Linyphia triangularis (Araneae: Linyphiidae) and Aphidoletes aphidimyza (Diptera: Cecidomyiidae) Are Promising Attractants for Aphidoletes aphidimyza (Diptera: Cecidomyiidae)

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Lansbermin-I, a disintegrin from Porthidium lansbergii lansbergii venom as a potential anticancer prototype: In vitro and in silico effects on cervical cancer cells

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Lansbermin-I, a disintegrin from Porthidium lansbergii lansbergii venom as a potential anticancer prototype: In vitro and in silico effects on cervical cancer cells

Abstract

We report the cytotoxic effects of Lansbermin-I, a disintegrin from Porthidium lansbergii lansbergii venom, on HeLa cervical cancer cells but not on leukemic, non-tumorigenic peripheral blood mononuclear cells (PBMCs) or fibroblast lines. Lansbermin-I reduced HeLa cell viability in a concentration-dependent manner, impaired adhesion to fibronectin and collagen, and inhibited migration and clonogenicity. Docking analysis suggested interaction with the RGD domain of integrin α5β1. These results identify Lansbermin-I as a potential antitumor prototype against cervical cancer.
Osorno-Valencia, D., Montoya-Gómez, A., Sevilla-Sánchez, M. J., Burbano-Guerrero, N., Mosquera-Escudero, M., & Jiménez-Charris, E. (2026). Lansbermin-I, a disintegrin from Porthidium lansbergii lansbergii venom as a potential anticancer prototype: In vitro and in silico effects on cervical cancer cells. Toxicon, 109063. https://doi.org/10.1016/j.toxicon.2026.109063