Hidden diversity in plain sight: four new species of Nemesia (Araneae: Mygalomorphae) from the Córdoba Province of Spain

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  Hidden diversity in plain sight: four new species of Nemesia (Araneae: Mygalomorphae) from the Córdoba Province of Spain Abstract A taxonomic revision of the species of Nemesia Audouin, 1826, distributed in the vicinity of Córdoba City, southern Spain, is presented. Four new species are described: Nemesia morana sp. nov. (female), N. kodama sp. nov. (male and female), N. rosae sp. nov. (male and female), and N. tamajoni sp. nov. (male and female). These species are distinguished by distinct morphological characters, including the shape of the spermathecae, palpal bulbs, and spinnerets, as well as by burrow architecture. Fieldwork was conducted across two of the three major habitat types in the region—the humid, forested mountains of Sierra Morena and the croplands and riparian forests of the Guadalquivir Valley—while the third, the “campiña”, which is mainly composed of agricultural landscapes, remains poorly explored. Sampling methods included pitfall trapping and the direct e...

Lansbermin-I, a disintegrin from Porthidium lansbergii lansbergii venom as a potential anticancer prototype: In vitro and in silico effects on cervical cancer cells

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Lansbermin-I, a disintegrin from Porthidium lansbergii lansbergii venom as a potential anticancer prototype: In vitro and in silico effects on cervical cancer cells

Abstract

We report the cytotoxic effects of Lansbermin-I, a disintegrin from Porthidium lansbergii lansbergii venom, on HeLa cervical cancer cells but not on leukemic, non-tumorigenic peripheral blood mononuclear cells (PBMCs) or fibroblast lines. Lansbermin-I reduced HeLa cell viability in a concentration-dependent manner, impaired adhesion to fibronectin and collagen, and inhibited migration and clonogenicity. Docking analysis suggested interaction with the RGD domain of integrin α5β1. These results identify Lansbermin-I as a potential antitumor prototype against cervical cancer.
Osorno-Valencia, D., Montoya-Gómez, A., Sevilla-Sánchez, M. J., Burbano-Guerrero, N., Mosquera-Escudero, M., & Jiménez-Charris, E. (2026). Lansbermin-I, a disintegrin from Porthidium lansbergii lansbergii venom as a potential anticancer prototype: In vitro and in silico effects on cervical cancer cells. Toxicon, 109063. https://doi.org/10.1016/j.toxicon.2026.109063