Differential Hematotoxic Activity of Southeast Asian Pit Viper Venoms: The Cross-Neutralizing Effect of Available Antivenoms

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  Image Credit: Creative Commons (some rights reserved) CC BY-NC Photo 111998430, (c) Nicholas Hess Differential Hematotoxic Activity of Southeast Asian Pit Viper Venoms: The Cross-Neutralizing Effect of Available Antivenoms Abstract Background/Objectives : Pit vipers (subfamily Crotalinae) are responsible for a large proportion of snakebite envenoming cases in Southeast Asia. Envenomation by these snakes commonly causes hematotoxic effects, including platelet dysfunction and coagulation disturbances. Although antivenom remains the mainstay of treatment, species-specific antivenoms are not available for several regional pit viper species. This study evaluated the hematotoxic activities of selected Southeast Asian pit viper venoms and the cross-neutralizing capacity of commercially available antivenoms.  Methods : Venoms from five medically important pit viper species— Calloselasma rhodostoma ,  Trimeresurus albolabris ,  T. hageni ,  T. purpureomaculatus , ...

Lansbermin-I, a disintegrin from Porthidium lansbergii lansbergii venom as a potential anticancer prototype: In vitro and in silico effects on cervical cancer cells

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Lansbermin-I, a disintegrin from Porthidium lansbergii lansbergii venom as a potential anticancer prototype: In vitro and in silico effects on cervical cancer cells

Abstract

We report the cytotoxic effects of Lansbermin-I, a disintegrin from Porthidium lansbergii lansbergii venom, on HeLa cervical cancer cells but not on leukemic, non-tumorigenic peripheral blood mononuclear cells (PBMCs) or fibroblast lines. Lansbermin-I reduced HeLa cell viability in a concentration-dependent manner, impaired adhesion to fibronectin and collagen, and inhibited migration and clonogenicity. Docking analysis suggested interaction with the RGD domain of integrin α5β1. These results identify Lansbermin-I as a potential antitumor prototype against cervical cancer.
Osorno-Valencia, D., Montoya-Gómez, A., Sevilla-Sánchez, M. J., Burbano-Guerrero, N., Mosquera-Escudero, M., & Jiménez-Charris, E. (2026). Lansbermin-I, a disintegrin from Porthidium lansbergii lansbergii venom as a potential anticancer prototype: In vitro and in silico effects on cervical cancer cells. Toxicon, 109063. https://doi.org/10.1016/j.toxicon.2026.109063