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The Venom Revolution in Biomedicine: Unlocking Nature’s Toxin Toolkit for Therapeutic Innovation
Abstract
Once known only for its deadly effects, venom is now valued for its medicinal potential. The transformation of venomous substances into therapeutic agents, focusing on the synergy between natural toxins and drugs, is a recent topic of interest to the scientific community worldwide. Venom is a concoction of various biomolecules, including proteins, enzymes, peptides, protease inhibitors, and more. This review focuses on different categories of venomous species, their venom composition, the mechanism of venom deployment, and the pharmacokinetics. Besides this, it also focuses on the technological innovations while tracing venom's medical use from ancient practices to modern therapies. Additionally, it addresses the challenges and future directions, such as regulatory obstacles related to the approval processes for venom-derived drugs, illustrating the ongoing evolution from toxins to cure.
Bose, D., Srinivasan, K., Patil, S. S., Nayak, A. G., & Hariharapura, R. C. (2026). The Venom Revolution in Biomedicine: Unlocking Nature’s Toxin Toolkit for Therapeutic Innovation. Toxicology Reports, 16, 102227. https://doi.org/10.1016/j.toxrep.2026.102227