Snakebite epidemiology in the State of Mexico, Mexico 2003-2024

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  Snakebite epidemiology in the State of Mexico, Mexico 2003-2024 Abstract In the State of Mexico, several venomous snakes have low median lethal doses, which therefore pose serious health risks. We analyzed the epidemiology of snakebites from 2003 to 2024 and examined their relationship with demographic, socioeconomic, and biological factors. Incidence rates and demographic characteristics were calculated, and Getis-Ord Gi* statistics were used to identify snakebite hotspots. We also applied Non-Metric Multi-Dimensional Scaling (NMDS) to explore associations between hotspot categories and socioeconomic conditions. The potential distribution of 14 venomous snake species was modelled to estimate venomous snake diversity across municipalities. A total of 3,972 cases were reported, with an increasing trend over time. Most bites occurred in summer, affecting mainly males aged 25-44. Hotspot analysis identified 27 municipalities as hotspots, 50 as not significant and 48 as coldspots. So...

Latrodectism in Europe (1973-2025): A systematic review of clinical manifestations, management and outcomes

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Latrodectism in Europe (1973-2025): a systematic review of clinical manifestations, management and outcomes

Abstract

Background

Latrodectus tredecimguttatus, the Mediterranean black widow spider, accounts for most clinically significant spider bites in Europe. Although its toxidrome has long been recognized, contemporary evidence is fragmented, and the evolving clinical spectrum – including emerging cardiac complications – has not been systematically reviewed.

Methods

We performed a systematic review of PubMed/MEDLINE and Scopus (inception-September 2025) following PRISMA 2020 guidelines. Eligible studies included case reports, case series, and observational datasets reporting confirmed or presumed L. tredecimguttatus envenomation in Europe. Data on demographics, clinical features, management, and outcomes were extracted and synthesized descriptively.

Results

Thirty-six publications met inclusion criteria, representing approximately 500 reported envenomations. Cases occurred mainly in Mediterranean agricultural regions during summer, most often affecting adult men. Severe local pain was nearly universal, accompanied by neuromuscular and autonomic features. Multiple reports documented cardiac involvement – including myocarditis, pulmonary edema, arrhythmias, and Takotsubo-like cardiomyopathy – highlighting an increasingly recognized complication pattern. Supportive therapy (analgesia, benzodiazepines) remained the primary treatment. Antivenom use, limited to a few European settings, was associated with rapid symptom relief and shorter hospitalization. The overall case fatality rate was ∼1.3%, with deaths mainly due to cardiogenic complications.

Conclusions

L. tredecimguttatus envenomation in Europe is uncommon yet clinically significant. While most patients recover with supportive care, emerging cardiac manifestations underscore the need for enhanced monitoring, improved antivenom availability, and deeper investigation into venom-induced cardiac toxicity.

Terzi, I., Delivalta, N., Ntoga, M., & Stamatiou, I. (2026). Latrodectism in Europe (1973-2025): A systematic review of clinical manifestations, management and outcomes. Toxicon, 109024. https://doi.org/10.1016/j.toxicon.2026.109024