Scorpion Venom Peptides: From Structural Scaffolds to Therapeutic Applications—A Focus on Antioxidant Mechanisms and Translational Perspectives

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  Scorpion Venom Peptides: From Structural Scaffolds to Therapeutic Applications—A Focus on Antioxidant Mechanisms and Translational Perspectives Abstract Scorpion venom peptides, with their stable disulfide backbone, compact structural framework, and highly selective regulation of ion channels, have long been regarded as important molecular probes in neuropharmacology. However, recent studies have revealed their potential for regulating oxidative stress, inflammation, and neuroprotection, making them a new research frontier. In this article, we focus on scorpion venom peptides as drugs, constructing an integrated knowledge framework from structural classification to clinical translation. First, scorpion venom peptides are systematically classified based on cysteine arrangement patterns and three-dimensional folding topology, and their structure–activity relationships are summarized. Based on this, the molecular mechanisms by which scorpion venom peptides regulate ion channels are ...

Parasitoidism of Aphonopelma hentzi (Girard, 1852) (Araneae: Theraphosidae) and first records of Pepsis mildei Stål, 1857 (Hymenoptera: Pompilidae) in Missouri, U.S.A.

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Parasitoidism of Aphonopelma hentzi (Girard, 1852) (Araneae: Theraphosidae) and first records of Pepsis mildei Stål, 1857 (Hymenoptera: Pompilidae) in Missouri, U.S.A.

The life history of wasps in the genus Pepsis Fabricius, 1804, colloquially known as ‘tarantula hawk-wasps’ or ‘tarantula hawks’, has been described by Williams (1956). The female wasp paralyzes her host, most often a mygalomorph spider, with a venomous sting and buries it in a burrow. Before leaving, the wasp lays an egg on the spider’s abdomen, which hatches into a larva that feeds on the tarantula and develops through multiple instars before pupating and then digging out of the chamber as an adult. While some tarantula hawks parasitize non-tarantula spider families of Mygalomorphae, many parasitize Theraphosidae (tarantulas) exclusively. These host capture events are well documented, but few Pepsis sightings have been documented at the northeasternmost distributional limit of Theraphosidae in North America, namely, the confluence of the Missouri and Mississippi River in east-central Missouri. This paper describes an observation of a species of Pepsis attempting to capture a host tarantula in the region and documents contemporary captures of Pepsis mildei Stål, 1857 in Missouri, a new record for the state and likely the species observed in the wasp-tarantula interaction.

Becky Hansis-O'Neill, Ted C. MacRae "Parasitoidism of Aphonopelma hentzi (Girard, 1852) (Araneae: Theraphosidae) and first records of Pepsis mildei Stål, 1857 (Hymenoptera: Pompilidae) in Missouri, U.S.A.," The Pan-Pacific Entomologist, 101(4), 305-311, (31 December 2025)