Snake Venom and Antivenom Pharmacology

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  SNAKE VENOM & ANTIVENOM Chemistry, Composition, Mechanisms and Pharmacology Abstract This integrated teaching session for Phase III MBBS students focused on the pharmacology and toxicology of snake venom and the principles of antivenom therapy. The lecture covered the chemistry, composition, mechanisms of action, and pharmacological effects of snake venoms and antivenoms. Rational use of antivenoms, indications, administration protocols, adverse reactions, and supportive management strategies were discussed. The session also highlighted the translational importance of venom-derived compounds in modern drug development. Recent advances in antivenom research, including recombinant human monoclonal antibodies, toxin-specific inhibitors, synthetic antibody technologies, and next-generation broad-spectrum antivenoms, were reviewed. Current discoveries and emerging approaches aimed at improving efficacy, safety, affordability, and accessibility of antivenom therapy were also explor...

Influence of the ABO system on the hemolytic activity of medically relevant Loxosceles venoms in Brazil

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Influence of the ABO system on the hemolytic activity of medically relevant Loxosceles venoms in Brazil

Abstract

Envenomation by Loxosceles spiders is an important public health issue, frequently associated with hemolysis. Although the ABO blood group system influences various diseases, its role in loxoscelism is poorly understood. This study evaluated the effect of ABO types on hemolysis induced by L. intermedia, L. gaucho, and L. laeta venoms, with and without complement. Blood type B erythrocytes showed reduced susceptibility to direct hemolysis, suggesting a potential protective effect and offering new insights for improving loxoscelism management.
Beltramino, M., Jiacomini, I. G., Prado-Costa, B., Fonseca, M. F., Degraf Muzzi, J. C., Ferreira de Moura, J., Minozzo, J. C., Becker-Finco, A., & Alvarenga, L. M. (2026). INFLUENCE OF THE ABO SYSTEM ON THE HEMOLYTIC ACTIVITY OF MEDICALLY RELEVANT LOXOSCELES VENOMS IN BRAZIL. Toxicon, 108994. https://doi.org/10.1016/j.toxicon.2026.108994