Recent advances in venom pharmacology reshaping venom-to-drug discovery

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  Recent advances in venom pharmacology reshaping venom-to-drug discovery Abstract Animal venoms represent rich sources of pharmacologically active molecules, yet their translation into clinical therapeutics has historically progressed slowly. Recent advances in AI-driven venomics, cryo-electron microscopy, and computational peptide engineering are helping to overcome long-standing barriers in venom-based drug discovery and accelerate therapeutic translation. Abd El-Aziz, T., De Waard, M., & Singh, B. (2026). Recent advances in venom pharmacology reshaping venom-to-drug discovery. Trends in Pharmacological Sciences . Advance online publication. https://doi.org/10.1016/j.tips.2026.06.006

The mitochondrial genome of Bothriocyrtum californicum (O. Pickard-Cambridge, 1874) (Araneae, Halonoproctidae) from ultraconserved elements (UCEs)

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The mitochondrial genome of Bothriocyrtum californicum (O. Pickard-Cambridge, 1874) (Araneae, Halonoproctidae) from ultraconserved elements (UCEs)

Abstract

The mitochondrial genome of Bothriocyrtum californicum (O. Pickard-Cambridge, 1874) has been completely sequenced and annotated for the first time. This trap-door spider is found in California, United States. We used SPAdes to assemble contigs and the mitogenome was extracted from the resulting contigs. The mitogenome was annotated using MITOS2 and by comparing to other species in the order Araneae. The mitogenome is 14,081 base pairs, and includes 22 transfer RNA (tRNA) genes, 13 protein coding genes (PCG), 2 ribosomal RNA (rRNA) genes, and a control region. This is the first sequenced and annotated mitogenome for this species, genus, and the family Halonoproctidae.

Kern, O. C., & Patrick, L. B. (2026). The mitochondrial genome of Bothriocyrtum californicum (O. Pickard-Cambridge, 1874) (Araneae, Halonoproctidae) from ultraconserved elements (UCEs). Mitochondrial DNA Part B, 11(1), 121–125. https://doi.org/10.1080/23802359.2025.2603825