The chromosome-level genome of Mesobuthus martensii provides insights into its evolution and the diversity of venom peptides

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  The chromosome-level genome of Mesobuthus martensii provides insights into its evolution and the diversity of venom peptides Abstract Mesobuthus martensii , the source species of the traditional Chinese medicine “Quanxie”, has long been utilized for its therapeutic properties. Venom peptides are recognized as the major active molecular basis of these pharmacological activities. Despite this, their development as therapeutic agents remains poorly explored. In this study, we performed an integrated multi-omics investigation to systematically explore the venom peptides of Mesobuthus martensii . We generated a chromosome-level genome assembly of Mesobuthus martensii using third-generation sequencing technologies, yielding a genome size of 1.08 Gb with a contig N50 of 46.46 Mb. Integrated genomic and transcriptomic analyses led to the identification of 51 putative novel venom peptide candidates. From the broader venom peptide set, five lysine- and arginine-rich candidates were select...

The mitochondrial genome of Bothriocyrtum californicum (O. Pickard-Cambridge, 1874) (Araneae, Halonoproctidae) from ultraconserved elements (UCEs)

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The mitochondrial genome of Bothriocyrtum californicum (O. Pickard-Cambridge, 1874) (Araneae, Halonoproctidae) from ultraconserved elements (UCEs)

Abstract

The mitochondrial genome of Bothriocyrtum californicum (O. Pickard-Cambridge, 1874) has been completely sequenced and annotated for the first time. This trap-door spider is found in California, United States. We used SPAdes to assemble contigs and the mitogenome was extracted from the resulting contigs. The mitogenome was annotated using MITOS2 and by comparing to other species in the order Araneae. The mitogenome is 14,081 base pairs, and includes 22 transfer RNA (tRNA) genes, 13 protein coding genes (PCG), 2 ribosomal RNA (rRNA) genes, and a control region. This is the first sequenced and annotated mitogenome for this species, genus, and the family Halonoproctidae.

Kern, O. C., & Patrick, L. B. (2026). The mitochondrial genome of Bothriocyrtum californicum (O. Pickard-Cambridge, 1874) (Araneae, Halonoproctidae) from ultraconserved elements (UCEs). Mitochondrial DNA Part B, 11(1), 121–125. https://doi.org/10.1080/23802359.2025.2603825