Beyond Venom and Constriction: Bite Performance and Trophic Ecology in the Genus Drymarchon

  Beyond Venom and Constriction: Bite Performance and Trophic Ecology in the Genus Drymarchon Abstract Snakes exhibit extreme cranial kinesis that facilitates ingestion of prey with large cross-sectional area, but this ability is widely predicted to reduce bite performance due to decreased structural rigidity. Consequently, most large-bodied snakes rely on envenomation or constriction to subdue prey prior to ingestion. Species within the genus Drymarchon represent a notable exception: these large, non-venomous, non-constricting snakes routinely consume a wide range of prey, including large and potentially dangerous vertebrates, using only simple seizing and pinioning behaviors. Here, we quantify bite performance in three species of Drymarchon ( D. corais, D. couperi, and D. melanurus ), examine morphological predictors of biting performance, compare biting pressure to constriction pressure in similarly sized snakes, and synthesize dietary records across the genus. Our results sh...

Recent advances in venom pharmacology reshaping venom-to-drug discovery

 


Recent advances in venom pharmacology reshaping venom-to-drug discovery

Abstract

Animal venoms represent rich sources of pharmacologically active molecules, yet their translation into clinical therapeutics has historically progressed slowly. Recent advances in AI-driven venomics, cryo-electron microscopy, and computational peptide engineering are helping to overcome long-standing barriers in venom-based drug discovery and accelerate therapeutic translation.
Abd El-Aziz, T., De Waard, M., & Singh, B. (2026). Recent advances in venom pharmacology reshaping venom-to-drug discovery. Trends in Pharmacological Sciences. Advance online publication. https://doi.org/10.1016/j.tips.2026.06.006