Snake Venom and Antivenom Pharmacology

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  SNAKE VENOM & ANTIVENOM Chemistry, Composition, Mechanisms and Pharmacology Abstract This integrated teaching session for Phase III MBBS students focused on the pharmacology and toxicology of snake venom and the principles of antivenom therapy. The lecture covered the chemistry, composition, mechanisms of action, and pharmacological effects of snake venoms and antivenoms. Rational use of antivenoms, indications, administration protocols, adverse reactions, and supportive management strategies were discussed. The session also highlighted the translational importance of venom-derived compounds in modern drug development. Recent advances in antivenom research, including recombinant human monoclonal antibodies, toxin-specific inhibitors, synthetic antibody technologies, and next-generation broad-spectrum antivenoms, were reviewed. Current discoveries and emerging approaches aimed at improving efficacy, safety, affordability, and accessibility of antivenom therapy were also explor...

Scorpion envenoming by Parabuthus is a public health concern in Namibia

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Scorpion envenoming by Parabuthus is a public health concern in Namibia

Abstract

Scorpion stings by members of the genus Parabuthus (Buthidae) can lead to life-threatening envenoming. Namibia harbours a rich diversity of scorpions, including seventeen species of the highly venomous genus Parabuthus, although the biology and medical relevance of most species are poorly documented. Severe envenoming is caused by at least P. granulatus, P. villosus, P. kraepelini and P. schlechteri, which are considered to be of particular importance. Data on epidemiology, venom composition and variation, and clinical effects remain scarce. A lack of effective antivenom and long distances to hospitals in rural areas complicate clinical management and compromise patient outcomes.