AaTs-1, a Tetrapeptide from Scorpion Venom Mitigates Demyelination and Neuroinflammation in a Cuprizone-Induced Model of Multiple Sclerosis

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  AaTs-1, a Tetrapeptide from Scorpion Venom Mitigates Demyelination and Neuroinflammation in a Cuprizone-Induced Model of Multiple Sclerosis Abstract Purpose This study focuses on the evaluation of the therapeutic potential of Tetrascorpin-1 (AaTs-1), a tetrapeptide isolated from Androctonus australis hector venom, proposed as a putative formyl peptide receptor 2 (FPR2) antagonist, in a cuprizone-induced murine model of Multiple sclerosis (MS), a chronic autoimmune and inflammatory disease of the central nervous system. Methods Acute demyelination was induced in mice by administering cuprizone (0.2% w/w in the diet) for six weeks. During the sixth week of cuprizone intake, demyelinated mice received intranasal administration of AaTs-1 at a dose of 50–100 µg/kg for five consecutive days, with 24-hour intervals between treatments. Results Behavioral assessments, immunological assays, and histological analyses revealed that AaTs-1 improved body weight, reduced behavioral impairments...

First records of Hippasosa ghost (Jocque & Jocqué, 2017) (Araneae, Lycosidae) outside of the type locality in northwestern Madagascar

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First records of Hippasosa ghost (Jocque & Jocqué, 2017) (Araneae, Lycosidae) outside of the type locality in northwestern Madagascar

Abstract

The Malagasy endemic wolf spider Hippasosa ghost (Jocque & Jocqué, 2017), previously known from a single small patch of sandy habitat adjacent to a permanent lake in the Mariarano Classified Forest in northwestern Madagascar, is recorded from two additional localities with similar habitat along the Mariarano River, 10 km and 45 km from the type locality. These finds indicate the possibility that this highly specialized species could have a larger distribution than originally thought, but also they show the importance of protecting such vulnerable habitats.

Pett BL, Escobar-Toledo J, de Beer L, Murray KI, Rakotorahalahy M, Siméon F, Rivoson JL (2025) First records of Hippasosa ghost (Jocque & Jocqué, 2017) (Araneae, Lycosidae) outside of the type locality in northwestern Madagascar. Check List 21(6): 1257-1261. https://doi.org/10.15560/21.6.1257