Barietin, a snake venom vascular endothelial growth factor from puff adder Bitis arietans venom, increases the heart rate with minor effect on blood pressure in rats

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  Barietin, a snake venom vascular endothelial growth factor from puff adder Bitis arietans venom, increases the heart rate with minor effect on blood pressure in rats ABSTRACT Snake venom vascular endothelial growth factors (svVEGFs) are homodimeric proteins comprising two equal subunits bound by two intermolecular disulfide bonds. The main biological effects of svVEGFs are local vasodilatation, increasing of vascular permeability, and hypotension. Barietin, a svVEGF purified from the venom of puff adder Bitis arietans , differs from other representatives of this toxin family by its shortened C-terminal amino acid sequence. No data about barietin effects on hemodynamics are available. Studying those in rats we found that barietin at a dose of 1 mg/kg significantly increased heart rate, exerting only a minor influence on blood pressure. In this respect, it differs from other svVEGFs having a significant effect on blood pressure. We aimed to find the barietin active fragment which m...

The genome sequence of an orb-weaver spider, Araneus angulatus Clerck, 1757 (Araneae: Araneidae)

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The genome sequence of an orb-weaver spider, Araneus angulatus Clerck, 1757 (Araneae: Araneidae)

Abstract

We present a genome assembly from an individual female Araneus angulatus (orb-weaver spider; Arthropoda; Arachnida; Araneae; Araneidae). The assembly contains two haplotypes with total lengths of 2 980.91 megabases and 2 941.08 megabases. Most of haplotype 1 (94.74%) is scaffolded into 28 chromosomal pseudomolecules. Haplotype 2 was assembled to scaffold level. The mitochondrial genome has also been assembled, with a length of 14.53 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.


Raper CM, Sivell O, Natural History Museum Genome Acquisition Lab et al. The genome sequence of an orb-weaver spider, Araneus angulatus Clerck, 1757 (Araneae: Araneidae) [version 1; peer review: awaiting peer review]. Wellcome Open Res 2025, 10:656 (https://doi.org/10.12688/wellcomeopenres.25196.1)