Scorpion Venom Peptides: From Structural Scaffolds to Therapeutic Applications—A Focus on Antioxidant Mechanisms and Translational Perspectives

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  Scorpion Venom Peptides: From Structural Scaffolds to Therapeutic Applications—A Focus on Antioxidant Mechanisms and Translational Perspectives Abstract Scorpion venom peptides, with their stable disulfide backbone, compact structural framework, and highly selective regulation of ion channels, have long been regarded as important molecular probes in neuropharmacology. However, recent studies have revealed their potential for regulating oxidative stress, inflammation, and neuroprotection, making them a new research frontier. In this article, we focus on scorpion venom peptides as drugs, constructing an integrated knowledge framework from structural classification to clinical translation. First, scorpion venom peptides are systematically classified based on cysteine arrangement patterns and three-dimensional folding topology, and their structure–activity relationships are summarized. Based on this, the molecular mechanisms by which scorpion venom peptides regulate ion channels are ...

A New Species of Wishbone Spider Genus Damarchus from Doi Inthanon National Park, Thailand (Mygalomorphae: Bemmeridae)

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A New Species of Wishbone Spider Genus Damarchus from Doi Inthanon National Park, Thailand (Mygalomorphae: Bemmeridae)

Abstract

The wishbone spider genus Damarchus, belonging to the family Bemmeridae, encompasses four recognized genera: Atmeto-chilus, Damarchus, Homostola, and Spiroctenus. Current distribution records indicate that Atmetochilus and Damarchus are exclusively found in Asia. To date, ten species of Damarchus have been documented, with three species reported in Thailand. However, our field surveys conducted since 2015 have identified multiple undescribed species within the genus that remain unclassified. Through detailed morphological analyses, we describe a new species, Damarchus sirindhornae Kunsete & Warrit, sp. nov., discovered in Doi Inthanon National Park. This species is classified within the workmani-group but can be distinguished from other members of the group by the absence of spines on the male coupling spur and the absence of secondary receptacles on the female spermathecae.

Kunsete, C., Sivayyapram, V., Thanoosing, C., Traiyasut, P., & Warrit, N. (2025). A New Species of Wishbone Spider Genus Damarchus from Doi Inthanon National Park, Thailand (Mygalomorphae: Bemmeridae). Tropical Natural History, 25(8), 390–398. retrieved from https://li01.tci-thaijo.org/index.php/tnh/article/view/266793