Qualitative and Quantitative Proteomic Analysis of Venoms from Mexican Rattlesnakes

Posted by
  Qualitative and Quantitative Proteomic Analysis of Venoms from Mexican Rattlesnakes Abstract Despite the vast biodiversity of Mexican vipers, venom of endemic species has been barely studied. Here we analyzed the venom composition of three endemic species of rattlesnakes: Crotalus aquilus , C. triseriatus , and C. ravus . We used quantitative chromato-mass-spectrometry and compared venoms with C. molossus , a species commonly found in North America, in a comparative and phylogenetic framework. In total, we identified 165 proteins grouped in 19 main protein families, consistent with previous reports for viperid venoms. In C. aquilus and C. triseriatus , the most predominant protein-family type was Serine Proteases, and in C. triseriatus and C. molossus it was Snake Venom Metalloproteases. The Label-free quantification revealed a high proportion of Snake Venom Metalloproteases in C. aquilus , C. triseriatus , and C. molossus , reaching 28–47% of the total venom. In contrast, in ...

Successful Management of Intravascular Hemolysis Caused by Systemic Loxoscelism With Antivenom: A Case Report

Posted by

 


Successful Management of Intravascular Hemolysis Caused by Systemic Loxoscelism With Antivenom: A Case Report

Abstract

Spider bites, particularly from Loxosceles species, pose a public health concern in Mexico. A case of systemic loxoscelism in a 33-year-old woman who developed acute intravascular hemolysis is presented. The patient was successfully treated with blood transfusions and Reclusmyn, a Mexican antivenom. Her clinical and laboratory improvement supports the therapeutic value of antivenom in severe envenomation. This case highlights the importance of early suspicion, recognition, and targeted treatment to prevent complications and improve outcomes.

Guadarrama-Fernández C, Longino J A, Villalba-Ríos N, et al. (September 05, 2025) Successful Management of Intravascular Hemolysis Caused by Systemic Loxoscelism With Antivenom: A Case Report. Cureus 17(9): e91678. doi:10.7759/cureus.91678