Distinct pathophysiological mechanisms of Heterometrus laoticus and Lychas mucronatus scorpion venoms on cardiovascular and renal functions

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  Distinct pathophysiological mechanisms of Heterometrus laoticus and Lychas mucronatus scorpion venoms on cardiovascular and renal functions Abstract Background:    Heterometrus laoticus and Lychas mucronatus are widely distributed in Southeast Asia, yet their pathophysiological effects of both venoms remain poorly characterized due to low human fatality rates. This study compared their venom compositions and acute cardiovascular and renal effects. Methods:   Anesthetized male New Zealand White rabbits were monitored for blood pressure (BP), heart rate (HR), and renal clearance following intravenous administration of crude venom (0.5 mg/kg). Venom components were identified via LC-MS/MS, and hematological/biochemical parameters were assessed. Results:    H. laoticus venom induced a rapid, transient hypotension ( p < 0.05), followed by a mild, prolonged hypotensive phase (up to 120 min). Conversely, L. mucronatus venom elicited a biphasic response: ...

Successful Management of Intravascular Hemolysis Caused by Systemic Loxoscelism With Antivenom: A Case Report

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Successful Management of Intravascular Hemolysis Caused by Systemic Loxoscelism With Antivenom: A Case Report

Abstract

Spider bites, particularly from Loxosceles species, pose a public health concern in Mexico. A case of systemic loxoscelism in a 33-year-old woman who developed acute intravascular hemolysis is presented. The patient was successfully treated with blood transfusions and Reclusmyn, a Mexican antivenom. Her clinical and laboratory improvement supports the therapeutic value of antivenom in severe envenomation. This case highlights the importance of early suspicion, recognition, and targeted treatment to prevent complications and improve outcomes.

Guadarrama-Fernández C, Longino J A, Villalba-Ríos N, et al. (September 05, 2025) Successful Management of Intravascular Hemolysis Caused by Systemic Loxoscelism With Antivenom: A Case Report. Cureus 17(9): e91678. doi:10.7759/cureus.91678