Transcriptomic Insights Into the Evolution of Snake Venom: Mechanisms, Diversity, and Adaptation

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  Transcriptomic Insights Into the Evolution of Snake Venom: Mechanisms, Diversity, and Adaptation Abstract Snake venoms are evolutionarily refined biochemical arsenals composed of diverse toxins with complex functional roles in predation, defense, and competition. Over the past 2 decades, transcriptomic approaches have transformed venom research by enabling high-resolution insights into gene expression dynamics, molecular diversity, and the evolutionary mechanisms driving venom variation across lineages. In this review, we present a comprehensive synthesis of snake venom transcriptomics literature and propose a conceptual framework structured around three major axes: (1) gene family expansion through duplication and neofunctionalization; (2) regulatory complexity encompassing transcriptional, posttranscriptional, and epigenetic modulation; and (3) ecological selection pressures shaping venom profiles in response to diet, habitat, and interspecific interactions. We integrate findin...

From the sting to the laboratory: A review of the venom peptides of social wasps (Hymenoptera: Vespidae)

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From the sting to the laboratory: A review of the venom peptides of social wasps (Hymenoptera: Vespidae)

Abstract

Social wasps make up a significant part to the diversity of the Hymenoptera order, one of the most varied insect groups. Beyond their ecological importance, these insects use their venom for defense, protecting their colonies. The venom of social wasps are rich in biologically active substances, including biogenic amines, peptides, proteins, enzymes, allergens, and volatile compounds. These substances can trigger various immune responses, such as allergic reactions and inflammation, and certain peptides demonstrate antimicrobial, anti-inflammatory, antitumor, anticoagulant, and anticancer properties. However, the limited availability of venom and the lack of studies of function for its bioactive compounds remain challenges to its effective utilization. This review compiles 124 peptides isolated from social wasps, highlighting their relevance in biotechnology and medicine, while also discussing their limitations and potential applications. These peptides were isolated from 39 species of social wasps worldwide, underscoring the potential of these insects' venom as a promising source for developing new pharmaceutical products and as a catalyst for drug discovery. Additionally, this work emphasizes a significant gap in research on social wasps collected in the Brazilian Amazon.
Brito, S., Alves, M. N. R., & Somavilla, A. (2025). From the sting to the laboratory: A review of the venom peptides of social wasps (Hymenoptera: Vespidae). Toxicon, 108566. https://doi.org/10.1016/j.toxicon.2025.108566