Could venom-derived therapeutics resolve treatment resistance in refractory EAC?

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  Could venom-derived therapeutics resolve treatment resistance in refractory EAC? Abstract The incidence of esophageal adenocarcinoma is rising in Western countries. Despite advances in chemotherapy and immunotherapy, the prognosis remains poor, with an overall 5-year survival rate below 15%. A major challenge is the cancer’s poor and often unpredictable response to current treatments. Animal venoms represent a promising yet underexplored source of therapeutic agents, offering millions of structurally diverse and highly potent bioactive peptides that can modulate a wide array of molecular targets. However, only a small fraction of these peptides has been pharmacologically characterized. This review presents the therapeutic potential of venom-derived peptides in cancer treatment, summarizes the role of ion channels in esophageal adenocarcinoma (EAC), and discusses peptides targeting ion channels that may offer new opportunities for future EAC treatment. Freuville L, Matthys C, Gill...

Review of the wolf spider genus Acantholycosa Dahl, 1908 from China (Araneae, Lycosidae)

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Review of the wolf spider genus Acantholycosa Dahl, 1908 from China (Araneae, Lycosidae)

Abstract

The genus Acantholycosa Dahl, 1908 from China is reviewed, including five species: A. aborigenica Zyuzin & Marusik, 1988, A. lignaria (Clerck, 1757), A. sterneri (Marusik, 1993), A. zang sp. nov. (♂♀) and A. zhangi sp. nov. (♂♀). Acantholycosa aborigenica and A. sterneri are recorded from China for the first time. Detailed descriptions are presented, along with photos of the habitus and copulatory organs, and a distribution map.

Zhang X-Y, Zhang Z-S, Wang L-Y (2025) Review of the wolf spider genus Acantholycosa Dahl, 1908 from China (Araneae, Lycosidae). ZooKeys 1240: 239-256. https://doi.org/10.3897/zookeys.1240.146399