Ziyuglycoside I Attenuates Deinagkistrodon acutus Venom–Induced Injury in Renal Tubular Epithelial Cells by Modulating PAR1–NLRP3–IL-1β Signaling

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  Ziyuglycoside I Attenuates Deinagkistrodon acutus Venom–Induced Injury in Renal Tubular Epithelial Cells by Modulating PAR1–NLRP3–IL-1β Signaling Abstract Introduction Sanguisorba officinalis L. ( Di Yu ) has traditionally been used for snakebite treatment. Ziyuglycoside I, a major bioactive constituent of Di Yu , exhibits anti-inflammatory activity, but its role in snake venom-associated renal injury remains unclear. This study aimed to investigate its potential protective effects against Deinagkistrodon acutus venom (DAV)-induced renal tubular epithelial cell injury in vitro. Methods HK-2 cells were exposed to DAV to establish an in vitro renal tubular epithelial injury model. Cellular metabolic activity and intracellular ATP levels were assessed using Cell Counting Kit-8 and CellTiter-Glo assays, respectively. DAV-induced molecular alterations were examined by transcriptomic sequencing, bioinformatic analysis, western blotting, and qRT-PCR. PAR1 knockdown and pharmacological...

Scorpions of the Horn of Africa (Arachnida: Scorpiones). Part XXXV. Parabuthus starhai sp. n. from Somalia (Puntland) (Buthidae)

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Scorpions of the Horn of Africa (Arachnida: Scorpiones). Part XXXV. Parabuthus starhai sp. n. from Somalia (Puntland) (Buthidae)

Abstract


A new species Parabuthus starhai sp. n. from Somalia (Puntland) is described. Combination of two characters, pectine teeth number 56–59 in both sexes and pedipalp chela length/ width ratio 3.65 in male and 5.47 in female differ P. starhai sp. n. from all other species in the region. Included is also a map of distribution of Parabuthus species in the Horn of Africa.

Kovařík, F. 2025 . Scorpions of the Horn of Africa (Arachnida: Scorpiones). Part XXXV. Parabuthus starhai sp. n. from Somalia (Puntland) (Buthidae). Euscorpius, No. 405: 1-10. https://mds.marshall.edu/euscorpius/vol2025/iss405/1/