AaTs-1, a Tetrapeptide from Scorpion Venom Mitigates Demyelination and Neuroinflammation in a Cuprizone-Induced Model of Multiple Sclerosis

Posted by
  AaTs-1, a Tetrapeptide from Scorpion Venom Mitigates Demyelination and Neuroinflammation in a Cuprizone-Induced Model of Multiple Sclerosis Abstract Purpose This study focuses on the evaluation of the therapeutic potential of Tetrascorpin-1 (AaTs-1), a tetrapeptide isolated from Androctonus australis hector venom, proposed as a putative formyl peptide receptor 2 (FPR2) antagonist, in a cuprizone-induced murine model of Multiple sclerosis (MS), a chronic autoimmune and inflammatory disease of the central nervous system. Methods Acute demyelination was induced in mice by administering cuprizone (0.2% w/w in the diet) for six weeks. During the sixth week of cuprizone intake, demyelinated mice received intranasal administration of AaTs-1 at a dose of 50–100 µg/kg for five consecutive days, with 24-hour intervals between treatments. Results Behavioral assessments, immunological assays, and histological analyses revealed that AaTs-1 improved body weight, reduced behavioral impairments...

A new cave species of Isometrus Ehrenberg 1828 from Myanmar (Scorpiones: Buthidae)

Posted by

 

                      

A new cave species of Isometrus Ehrenberg 1828 from Myanmar (Scorpiones: Buthidae)

Abstract
A new species belonging to the genus Isometrus Ehrenberg 1828, subgenus Reddyanus Vachon, 1972, is described from Myanmar: Isometrus (Reddyanus) alessandroi sp. n., which was collected in Saddan Cave, located in Kayin State, in the East of the country. In recent years the number of new species added to both subgenera Isometrus and Reddyanus have increased remarkably. Nevertheless, none of these descriptions concerned Myanmar. This particular geographic situation as well as a combination of several morphological features led us to propose here this new species.
Eric Ythier, Wilson R. Lourenço. A new cave species of Isometrus Ehrenberg 1828 from Myanmar (Scorpiones: Buthidae). Faunitaxys, 2025, 13 (4), pp.1-6. ⟨10.57800/faunitaxys-13(04)⟩. ⟨hal-04912024⟩