Acute gonadal toxicity induced by Bothrops atrox venom in mice

Posted by
  Acute gonadal toxicity induced by Bothrops atrox venom in mice Abstract Bothrops atrox is responsible for most snakebite incidents in the Amazon region. Its venom is recognized for causing significant tissue damage and systemic effects. However, its effect on reproductive organs remains poorly explored. This study aimed to investigate the acute effects of B. atrox venom on testes and ovaries of adult mice. Male and female mice were exposed to B. atrox venom (½ LD 50 ) via four administration routes subcutaneous (SC), intramuscular (IM), intravenous (IV), and intraperitoneal (IP), followed by comprehensive assessment of gonadal histology, sperm function, oxidative stress biomarkers, antioxidant enzyme activities, and mRNA expression of inflammatory and apoptotic markers. Following B. atrox venom exposure, ovarian histological architecture remained preserved across all routes, whereas testicular tissue exhibited route-dependent injury ranging from moderate luminal apoptosis aft...

Advancements in Diagnostic Techniques for Scorpion Venom Identification: A Comprehensive Review

Posted by

 


Advancements in Diagnostic Techniques for Scorpion Venom Identification: A Comprehensive Review

Abstract

Scorpion envenomation's ignored public health problem in tropical and subtropical countries is alarming. Particularly dangerous for small children and the elderly, it can cause severe problems and even death. Recent studies have proposed the creation of rapid, easy, species-specific, and sensitive detection kits as an alternative to the methods currently used to identify scorpions. Unfortunately, there is currently no commercially available technology for detecting scorpion envenomation in clinical settings, especially in remote tropical health centres. This study delineates the most dangerous scorpion species globally and the advancements in identifying their stings in vitro or in envenomed plasma. Furthermore, we have highlighted the practical challenges associated with scorpion venom detection and the necessity for innovative, expedited, and more accessible detection kits in countries where scorpion envenomation poses a significant issue.
Puzari, U., Das, B., & Mukherjee, A. K. (2024). Advancements in Diagnostic Techniques for Scorpion Venom Identification: A Comprehensive Review. Toxicon, 108191. https://doi.org/10.1016/j.toxicon.2024.108191