Could venom-derived therapeutics resolve treatment resistance in refractory EAC?

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  Could venom-derived therapeutics resolve treatment resistance in refractory EAC? Abstract The incidence of esophageal adenocarcinoma is rising in Western countries. Despite advances in chemotherapy and immunotherapy, the prognosis remains poor, with an overall 5-year survival rate below 15%. A major challenge is the cancer’s poor and often unpredictable response to current treatments. Animal venoms represent a promising yet underexplored source of therapeutic agents, offering millions of structurally diverse and highly potent bioactive peptides that can modulate a wide array of molecular targets. However, only a small fraction of these peptides has been pharmacologically characterized. This review presents the therapeutic potential of venom-derived peptides in cancer treatment, summarizes the role of ion channels in esophageal adenocarcinoma (EAC), and discusses peptides targeting ion channels that may offer new opportunities for future EAC treatment. Freuville L, Matthys C, Gill...

New species and records of ground spiders (Araneae: Gnaphosidae) from Iraq

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New species and records of ground spiders (Araneae: Gnaphosidae) from Iraq

Abstract

Newly taxonomic and faunistic data on five ground spiders (Gnaphosidae) in Iraq are provided. Talanites gilgamesh sp. nov. is described as a new species, according to two females collected from Thi Qar Province. Minosia simeonica Levy, 1995 and Synaphosus shirin Ovtsharenko, Levy & Platnick, 1994 are reported from Iraq for the first time, representing two new generic records for the fauna of this country. Additionally, new localities are reported for T. sumericus Zamani & Marusik, 2022 and Minosiella intermedia Denis, 1958. Photographic documentation of specimens, including their copulatory organs and habitats, is provided alongside mapped records detailing the known distribution of the species.

Al-Khazali, Azhar Mohammed. 2024. “New Species and Records of Ground Spiders (Araneae: Gnaphosidae) from Iraq”. Ecologica Montenegrina 77 (August):12-23. https://doi.org/10.37828/em.2024.77.2.