Cyanidin-3-O-glucoside (C3G): A natural small-molecule compound for alleviating envenomation symptoms Induced by Bungarus multicinctus

Posted by
  By Yung-Lun Lin - https://www.inaturalist.org/photos/339509447 , CC BY 4.0, https://commons.wikimedia.org/w/index.php?curid=181835911 Cyanidin-3-O-glucoside (C3G): A natural small-molecule compound for alleviating envenomation symptoms Induced by Bungarus multicinctus Abstract Bungarus multicinctus (many-banded krait) ranks among the world’s most medically significant venomous snakes. Its venom, predominantly composed of α-bungarotoxin neurotoxins in a complex mixture, induces life-threatening respiratory paralysis, pulmonary failure, and often multi-organ dysfunction following envenomation. Building upon our discovery that the chemical dye Cy7-SE attenuates the toxicity of  Bungarus multicinctus  venom, this study employed network pharmacology to analyze molecular docking parameters between Cy7-SE and α-bungarotoxin. We subsequently applied computational virtual screening to identify natural small molecules alleviating symptoms of  B. multicinctus  envenomati...

Hypersensitivity vs. uncommonly severe local envenoming by the red-back spider, Latrodectus hasselti Thorell, 1870 (Araneae: Theridiidae)

Posted by

 


Hypersensitivity vs. uncommonly severe local envenoming by the red-back spider, Latrodectus hasselti Thorell, 1870 (Araneae: Theridiidae)

Highlights

  • •

    Widow spider envenoming commonly causes a recognizable syndrome, latrodectism

  • •

    Common features include pain, diaphoresis, myalgia, autonomic effects

  • •

    34-yr-old woman envenomed by red-back spider (Latrodectus hasselti) developed severe local edema

  • •

    Patient had a history of previous L. hasselti envenoming treated with antivenom

  • •

    Patient was effectively treated with antivenom

  • •

    Full resolution required one week

  • •

    Mixed atopy and venom-induced effects should be considered in some envenomed patients

Weinstein, S. A. (2024). Hypersensitivity vs. Uncommonly severe local envenoming by the red-back spider, Latrodectus hasselti Thorell, 1870 (Araneae: Theridiidae). Toxicon, 108077. https://doi.org/10.1016/j.toxicon.2024.108077