Recent advances in venom pharmacology reshaping venom-to-drug discovery

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  Recent advances in venom pharmacology reshaping venom-to-drug discovery Abstract Animal venoms represent rich sources of pharmacologically active molecules, yet their translation into clinical therapeutics has historically progressed slowly. Recent advances in AI-driven venomics, cryo-electron microscopy, and computational peptide engineering are helping to overcome long-standing barriers in venom-based drug discovery and accelerate therapeutic translation. Abd El-Aziz, T., De Waard, M., & Singh, B. (2026). Recent advances in venom pharmacology reshaping venom-to-drug discovery. Trends in Pharmacological Sciences . Advance online publication. https://doi.org/10.1016/j.tips.2026.06.006

A new genus of lyrate curtain-web spiders (Araneae: Mygalomorphae: Dipluridae) from southeastern Brazil, with two new species and revalidation of a formerly described species

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A new genus of lyrate curtain-web spiders (Araneae: Mygalomorphae: Dipluridae) from southeastern Brazil, with two new species and revalidation of a formerly described species

    

Abstract 


A new Brazilian genus of curtain-web spiders, family Dipluridae Simon, 1889, Harpathele gen. nov., is described, with Harpathele gymnognatha comb. nov. (Bertkau, 1880) (Rio de Janeiro state) as its type species. The new genus is a lyrate Diplurinae and it is known only from southeast Brazil. It may be recognized by the relatively small body, maxilla with dorsal transverse suture showing distinct curve at its basal third, a field of numerous long and thin setae above that suture, and a field of small rigid bristles below it, among other characters. Harpathele gymnognatha comb. nov. (Bertkau, 1880) is revalidated and redescribed, with the designation of a neotype and the first description of a male, based on specimens collected in its type locality that match the original description and illustrations, and is pointed as senior synonym of Diplura annectens (Bertkau, 1880). Additionally, two species of the new genus are described: Harpathele cariacica sp. nov., based on females from Espírito Santo state, and Harpathele salinas sp. nov., based on males from Rio de Janeiro state. 


Wermelinger-Moreira, G., Pedroso, D. R., Castanheira, P. de S. & Baptista, R. L. C. (2024). A new genus of lyrate curtain-web spiders (Araneae: Mygalomorphae: Dipluridae) from southeastern Brazil, with two new species and revalidation of a formerly described species. Arachnology 19(8): 1060-1073.