Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides

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  Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides Abstract Purpose Bradykinin-potentiating peptides (BPPs), found in snake venom, are known to modulate cardiovascular functions, but their susceptibility to enzymatic degradation remains poorly understood. Methods Models were generated using AlphaFold-Colab for five small BPPs (< 9 amino acids) that did not have experimentally solved structures, and those BPPs which had reliable predictions of structure (pLDDT > 80) were used for docking studies. Protein-peptide docking experiments were done using HADDOCK for studying the interaction between wild-type (WT) and mutant serratiopeptidase with BPPs. After selecting the best complex, simulation of the complex was done using molecular dynamics (MD) simulations for 100 ns and binding energy determination using MM/PBSA analysis. For checking the mechanical stability of the protein-peptide complexes...

First record of Stenoterommata platensis (Araneae: Pycnothelidae) in Santiago del Estero, Argentina and niche modelling to unveil its distributional pattern

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Photo 332815205, (c) Rocío Esmeralda Pose, some rights reserved (CC BY), uploaded by Rocío Esmeralda Pose

First record of Stenoterommata platensis (Araneae: Pycnothelidae) in Santiago del Estero, Argentina and niche modelling to unveil its distributional pattern

ABSTRACT

Stenoterommata platensis is distributed in Argentina and Uruguay along the La Plata River basin, characterized by a predominantly humid climate and moist habitats. However, this contribution reports the presence of S. platensis outside its known distribution range, accompanied by an analysis of distribution models to assess the influence of bioclimatic variables on distribution patterns. This research confirms the current presence of S. platensis in the Santiago del Estero province, indicating a significant expansion of its geographic range and its ability to thrive in drier and high-temperature environments. Niche modeling under past conditions (~20000 years ago) indicated suitable areas for the establishing of this species in the Dry Chaco.

Nicoletta, Micaela & Ferretti, Nelson. (2024). First record of Stenoterommata platensis (Araneae: Pycnothelidae) in Santiago del Estero, Argentina and niche modelling to unveil its distributional pattern. 2023. 1-9. 10.54905/disssi.v24i74.e89s1606.