Role of snake venom proteases and tissue factor in venom induced hemostatic disorders and local hemorrhage in mice

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  Role of snake venom proteases and tissue factor in venom induced hemostatic disorders and local hemorrhage in mice Abstract Bothrops jararaca venom (BjV) induces hemostatic and inflammatory manifestations. Tissue factor (TF) is essential for hemostasis, but aberrant TF expression can cause coagulopathy. We determined the effect of inhibition of BjV serine proteases and metalloproteinases, as well as host TF, on the systemic coagulopathy and local hemorrhage in envenomed mice. Venom serine proteases induced hypofibrinogenemia whereas venom metalloproteinases induced hemorrhage. TF did not contribute to venom-induced coagulopathy, but played a protective role in venom-induced bleeding in mice. Sachetto, A. T., Mackman, N., & Santoro, M. L. (2026). Role of snake venom proteases and tissue factor in venom induced hemostatic disorders and local hemorrhage in mice. Toxicon , 109299. https://doi.org/10.1016/j.toxicon.2026.109299

An update on the huntsman spider genus Uaiuara Rheims, 2013 (Araneae, Sparassidae, Sparianthinae)

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An update on the huntsman spider genus Uaiuara Rheims, 2013 (Araneae, Sparassidae, Sparianthinae)


Abstract

The genus Uaiuara Rheims is revisited. A new species is described, based on females from Iquitos, Peru and new distribution records for Uaiuara amazonica (Simon, 1880) and U. quyguaba Rheims, 2013 are provided. In addition, an identification key and updated distribution maps are provided for all species.


Rheims, C. A. (2024). An update on the huntsman spider genus Uaiuara Rheims, 2013 (Araneae, Sparassidae, Sparianthinae). Zootaxa 5410(4): 545-556. doi:10.11646/zootaxa.5410.4.5