Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides

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  Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides Abstract Purpose Bradykinin-potentiating peptides (BPPs), found in snake venom, are known to modulate cardiovascular functions, but their susceptibility to enzymatic degradation remains poorly understood. Methods Models were generated using AlphaFold-Colab for five small BPPs (< 9 amino acids) that did not have experimentally solved structures, and those BPPs which had reliable predictions of structure (pLDDT > 80) were used for docking studies. Protein-peptide docking experiments were done using HADDOCK for studying the interaction between wild-type (WT) and mutant serratiopeptidase with BPPs. After selecting the best complex, simulation of the complex was done using molecular dynamics (MD) simulations for 100 ns and binding energy determination using MM/PBSA analysis. For checking the mechanical stability of the protein-peptide complexes...

A NEW SPECIES OF SCORPIO LINNAEUS, 1758 FROM ALGERIA (SCORPIONES: SCORPIONIDAE) AND A NEW CASE OF VICARIANCE.

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Arachnides
Bulletin de Bibliographie et de Recherches

Editor: Gerard Dupre

A NEW SPECIES OF SCORPIO LINNAEUS, 1758 FROM ALGERIA (SCORPIONES: SCORPIONIDAE) AND A NEW CASE OF VICARIANCE.

Abstract

A new species of Scorpio Linnaeus, 1758 is described from the Atakor volcanic field in the
Hoggar massif, located in the South of Algeria. Scorpio atakor sp. nov. most certainly represents a
vicariant element of Scorpio tassili Lourenço & Rossi, 2016, species equally described from a massif
formation, the Tassili N’Ajjer, in the South of Algeria. Both species are distributed in high altitudes in
these massifs. Scorpio trarasensis Bouisset & Larrouy, 1962 stat. rev., stat. nov. is also restored from
its synonymy with Scorpio maurus maurus Linnaeus, 1758 and raised to species level. The number of
confirmed species of Scorpio in Algeria is raised to six.


1-10. A new species of Scorpio Linnaeus, 1758 from Algeria (Scorpiones: Scorpionidae)
and a new case of vicariance. Ythier E., Sadine S.E., Bengaid Y. & Lourenço W.R. Arachnides 113, 2024. https://www.ntnu.no/ub/scorpion-files/arachnides.php


As always, a special thanks to Gérard for sending me this latest issue of his publication.