Structural determinants of the scorpion venom peptide Uy234 reveal a membrane-disruptive mechanism in bacterial ESKAPE pathogens
Structural determinants of the scorpion venom peptide Uy234 reveal a membrane-disruptive mechanism in bacterial ESKAPE pathogens
Image credit: https://doi.org/10.3897/evolsyst.3.37464 - https://evolsyst.pensoft.net/article/37464/list/2/ (license), CC BY 4.0, https://commons.wikimedia.org/w/index.php?curid=86225311 Structural determinants of the scorpion venom peptide Uy234 reveal a membrane-disruptive mechanism in bacterial ESKAPE pathogens Abstract The growth-inhibiting effect of the peptide Uy234, present in the venom of the scorpion Urodacus yaschenkoi, has been investigated in two bacterial pathogens: Staphylococcus aureus ATCC 25923 and Acinetobacter baumannii AE12, the latter being a multidrug-resistant clinical isolate. In addition, its interaction with phospholipid bilayers has been studied using atomic force microscopy (AFM), permeability studies in GUVs, and molecular dynamics simulations. To this end, two inactivated variants of this peptide were analyzed: Uy234-C (non-amidated peptide) and Uy234-A (P9A mutant). Only the native peptide Uy234 exhibited bacteriostatic and bactericidal activity, wh...
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