Distinct pathophysiological mechanisms of Heterometrus laoticus and Lychas mucronatus scorpion venoms on cardiovascular and renal functions

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  Distinct pathophysiological mechanisms of Heterometrus laoticus and Lychas mucronatus scorpion venoms on cardiovascular and renal functions Abstract Background:    Heterometrus laoticus and Lychas mucronatus are widely distributed in Southeast Asia, yet their pathophysiological effects of both venoms remain poorly characterized due to low human fatality rates. This study compared their venom compositions and acute cardiovascular and renal effects. Methods:   Anesthetized male New Zealand White rabbits were monitored for blood pressure (BP), heart rate (HR), and renal clearance following intravenous administration of crude venom (0.5 mg/kg). Venom components were identified via LC-MS/MS, and hematological/biochemical parameters were assessed. Results:    H. laoticus venom induced a rapid, transient hypotension ( p < 0.05), followed by a mild, prolonged hypotensive phase (up to 120 min). Conversely, L. mucronatus venom elicited a biphasic response: ...

Scorpion Sting: A Reason for Failed Local Anesthetic Action (CASE REPORT)

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Abstract

Failed action of local anesthetics can be due to technical errors, but resistance to local anesthetic agents can also be a reason. Scorpion venom has the potential to cause antibodies to local anesthetics and genetic mutations in the receptors resulting in local anesthesia resistance. We would like to report two cases with a history of scorpion stings in the past where resistance to local anesthetic agents was seen. Local anesthesia resistance can be manifested as inadequate block or block failure. In such cases, the anesthesiologist should keep a history of scorpion bite in mind in areas where scorpion sting is common. Eliciting the history of scorpion bites should be a part of the routine preoperative protocol in areas where scorpion bites are frequent.

Dalal KS, Chellam S, Toal PV, Panse S. Scorpion Sting: A Reason for Failed Local Anesthetic Action. Res Inno in Anesth 2023; 8 (2):57-59. 

https://www.riajournal.com/abstractArticleContentBrowse/JRIA/41/8/2/34782/abstractArticle/Article