Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides

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  Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides Abstract Purpose Bradykinin-potentiating peptides (BPPs), found in snake venom, are known to modulate cardiovascular functions, but their susceptibility to enzymatic degradation remains poorly understood. Methods Models were generated using AlphaFold-Colab for five small BPPs (< 9 amino acids) that did not have experimentally solved structures, and those BPPs which had reliable predictions of structure (pLDDT > 80) were used for docking studies. Protein-peptide docking experiments were done using HADDOCK for studying the interaction between wild-type (WT) and mutant serratiopeptidase with BPPs. After selecting the best complex, simulation of the complex was done using molecular dynamics (MD) simulations for 100 ns and binding energy determination using MM/PBSA analysis. For checking the mechanical stability of the protein-peptide complexes...

First record of Latrodectus dahli Levi, 1959 the medically important spider species (Araneae: Theridiidae) and some data about it from Kashan County, Central Iran

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First record of Latrodectus dahli Levi, 1959 the medically important spider species (Araneae: Theridiidae) and some data about it from Kashan County, Central Iran

Abstract
The genus Latrodectus (Theridiidae) Walckenaer, 1805 includes species which are generally known as widow spiders, and are medically-important for their very neurotoxic venom. At present, there are 32 species of this genus in the world. The medical syndrome that is caused by their bites is reported as Latrodectism which can result in a variety of symptoms (in some rare cases, death) including sweating, the hardness of stomach muscles, aches and local pain. This descriptive study aimed to identify the habitats of the black widow spider (Latrodectus dahli) in the desert and mountainous areas of Kashan Country (Qamsar, Ghohrud, Kashan, Ardahal, and Ravand) in Isfahan Province and Naraq in Markazi Province, Iran, in September and October 2021. The results showed that Latrodectus dahli was found only in Ghohrud. It is noteworthy that female black widow spider was observed in this region with their egg capsules. Since Kashan County is among the natural habitats of the black widow spider, farmers and workers are recommended to wear special gloves and boots while at work. Key words : Black widow spider, Iran, Latrodectism, Latrodectus dahli.

I would like to thank Dr. Hamid Kassiri for sending me this manuscript via ResearchGate

Dehghani, Rouhullah & Kassiri, Hamid & Kassiri, Arian. (2023). First record of Latrodectus dahli Levi, 1959 the medically important spider species (Araneae: Theridiidae) and some data about it from Kashan County, Central Iran. Entomological Research. 47. 1021-1024. 10.5958/0974-4576.2023.00190.1. 

Journal of Entomological Research
Year : 2023, Volume : 47, Issue : suppl
First page : ( 1021) Last page : ( 1024)
Print ISSN : 0378-9519. Online ISSN : 0974-4576.
Article DOI : 10.5958/0974-4576.2023.00190.1

Online Published on 17 January, 2024.