Biofactories Applied to Future Antivenom Production

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  Image Credit: By Ssiltane - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=52242648 Biofactories Applied to Future Antivenom Production Abstract Background: Accidents caused by the  Loxosceles laeta  spider constitute a health problem in South America. Envenomation can lead to severe systemic manifestations, eventually compromising the patient’s life. Most regional health authorities consider antivenom administration the basis of effective treatment in the most serious cases. The availability of spider venom is the primary bottleneck for antivenom production. Herein, we present a novel biotechnological approach, based on the expression of recombinant versions of the most relevant toxin in loxoscelism, sphingomyelinase D (SphD), in insect larvae ( Spodoptera frugiperda ).  Methods: We produced two versions of SphD: one conserving its biological activities (wtSphD) and a second alternative that was designed to be genetically detoxified (dSphD...

Further notes on the fossorial wolf spiders of Central Asia and the Near East (Aranei, Lycosidae)

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Further notes on the fossorial wolf spiders of Central Asia and the Near East (Aranei, Lycosidae)

Abstract
The paper presents new taxonomic-faunistic data on 25 species of the fossorial Lycosidae (Aranei) from Central Asia and the Near East. The lectotype male is designated for Tarentula fedotovi Charitonov, 1946. New combinations have been proposed for four species: Alopecosa nigriventris (Schmidt, 1895), comb.n., stat.n. (ex Lycosa), Asiacosa ambigua Denis, 1947, comb.n. (ex Arctosa), A. asiatica Sytshevskaja, 1980, comb.n. (ex Lycosa), and A. kulagini Spassky, 1941, comb.n. (ex Lycosa). One genus – Asiacosa gen.n. (Central Asia) – and 10 species are described as new to science: viz., Alopecosa darvaz sp.n. (♀; Tajikistan), A. pamirica sp.n. (♀; Tajikistan), A. safidorak sp.n. (♀; Tajikistan), A. zonsteini sp.n. (♂♀; Uzbekistan), Asiacosa babatagh sp.n. (♀; Uzbekistan), Karakumosa ferganensis sp.n. (♀; Uzbekistan), K. ovtchinnikovi sp.n. (♂♀; Uzbekistan), K. severtsovi sp.n. (♀; Tajikistan), Lycosa uzbekistanica sp.n. (♀; Uzbekistan), Zyuzicosa kvak sp.n. (♂♀; Tajikistan). The name Karakumosa golestanica Shafaie, Nadolny et Mirshamsi, 2022, syn.n. is synonymized with K. turanica Logunov et Ponomarev, 2020. The unknown male is described for Lycosa aragogi Nadolny et Zamani, 2017 from Iran.


Logunov, Dmitri. (2023). Further notes on the fossorial wolf spiders of Central Asia and the Near East (Aranei, Lycosidae). Arthropoda Selecta. 32. 475-512. 10.15298/arthsel.32.4.12. via ResearchGate and Journals of KMK