Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides

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  Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides Abstract Purpose Bradykinin-potentiating peptides (BPPs), found in snake venom, are known to modulate cardiovascular functions, but their susceptibility to enzymatic degradation remains poorly understood. Methods Models were generated using AlphaFold-Colab for five small BPPs (< 9 amino acids) that did not have experimentally solved structures, and those BPPs which had reliable predictions of structure (pLDDT > 80) were used for docking studies. Protein-peptide docking experiments were done using HADDOCK for studying the interaction between wild-type (WT) and mutant serratiopeptidase with BPPs. After selecting the best complex, simulation of the complex was done using molecular dynamics (MD) simulations for 100 ns and binding energy determination using MM/PBSA analysis. For checking the mechanical stability of the protein-peptide complexes...

New data on the wolf spiders (Araneae: Lycosidae) of Iraq

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New data on the wolf spiders (Araneae: Lycosidae) of Iraq

Abstract

New data on the wolf spiders of Iraq are provided. Two species, Arctosa similis Schenkel, 1938 and Lycosa piochardi Simon, 1876, are reported from Iraq for the first time, and additional records and a redescription are provided for Evippa amitaii Armiach Steinpress, Alderweireldt, Cohen, Chipman & Gavish-Regev, 2021. Photographs of specimens of both sexes of all three species and their copulatory organs and habitats are provided, and the known distribution records for the last two species, are mapped.

Al-Khazali, A. M., Al-Abbad, M. Y., Fomichev, A. A., & Kachel, H. S. (2023). New data on the wolf spiders (Araneae: Lycosidae) of Iraq. Ecologica Montenegrina, 67, 101–116. https://doi.org/10.37828/em.2023.67.12