Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides

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  Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides Abstract Purpose Bradykinin-potentiating peptides (BPPs), found in snake venom, are known to modulate cardiovascular functions, but their susceptibility to enzymatic degradation remains poorly understood. Methods Models were generated using AlphaFold-Colab for five small BPPs (< 9 amino acids) that did not have experimentally solved structures, and those BPPs which had reliable predictions of structure (pLDDT > 80) were used for docking studies. Protein-peptide docking experiments were done using HADDOCK for studying the interaction between wild-type (WT) and mutant serratiopeptidase with BPPs. After selecting the best complex, simulation of the complex was done using molecular dynamics (MD) simulations for 100 ns and binding energy determination using MM/PBSA analysis. For checking the mechanical stability of the protein-peptide complexes...

Review of the American genus Bolostromus Ausserer, 1875 with the description of fourteen new species (Araneae, Cyrtaucheniidae)

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Review of the American genus Bolostromus Ausserer, 1875 with the description of fourteen new species (Araneae, Cyrtaucheniidae)

Abstract

The family Cyrtaucheniidae is seldom found in the Americas, only 10 species are known to occur. Herein we described fourteen new species for the family Cyrtaucheniidae, all belonging to the genus Bolostromus from Central America and South America: Bolostromus busu n. sp. (female); B. devriesi n. sp. (female); B. epiphyticus n. sp. (male, female); B. fonsecai n. sp. (male); B. hubeni n. sp. (male, female); B. italoi n. sp. (female); B. laheredia n. sp. (male); B. losrios n. sp. (male); B. nischki n. sp. (male); B. urku n. sp. (male), B. primus n. sp. (male); B. pristirana n. sp. (male); B. stridulator n. sp. (male), and B. valdivia n. sp. (female). Photographs of the type specimens of: Bolostromus fauna (male and female); Bolostromus gaujoni (male); B. holguinensis (female juvenile); B. insularis (female juvenile); B. pulchripes (female); B. riveti (male) and, B. venustus (female) are provided, as well as a distribution map of all species.

  • NADINE DUPÉRRÉMuseum of Nature Hamburg; Leibniz Institute for the Analysis of Biodiversity Change (LIB); Center for Taxonomy and Morphology; Martin-Luther-King-Platz 3; Hamburg; Germany Research Associate; American Museum of Natural History; New York; NY; U.S.A.https://orcid.org/0000-0003-2195-878X