Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides

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  Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides Abstract Purpose Bradykinin-potentiating peptides (BPPs), found in snake venom, are known to modulate cardiovascular functions, but their susceptibility to enzymatic degradation remains poorly understood. Methods Models were generated using AlphaFold-Colab for five small BPPs (< 9 amino acids) that did not have experimentally solved structures, and those BPPs which had reliable predictions of structure (pLDDT > 80) were used for docking studies. Protein-peptide docking experiments were done using HADDOCK for studying the interaction between wild-type (WT) and mutant serratiopeptidase with BPPs. After selecting the best complex, simulation of the complex was done using molecular dynamics (MD) simulations for 100 ns and binding energy determination using MM/PBSA analysis. For checking the mechanical stability of the protein-peptide complexes...

First records and DNA barcoding of Argiope trifasciata (Forsskål, 1775) (Araneae, Araneidae) in Greece

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First records and DNA barcoding of Argiope trifasciata (Forsskål, 1775) (Araneae, Araneidae) in Greece

Abstract
Argiope trifasciata is a nearly cosmopolitan orb-weaver whose presence in Europe has been documented only in recent decades. Here, we report the first records of the species from Greece, based on a collected voucher specimen from Rhodes, which was morphologically and genetically examined, and additional citizen-science observations from Rhodes, Kos, and Crete. The Rhodes sequence was identical to the Cyprus sequence across the 611-bp COI alignment, and the two sequences were recovered together within the strongly supported Old World-associated Clade. These records fill a distributional gap between the western and eastern Mediterranean, correspond to projections in GLM-based species distribution modelling and extend the documented range of A. trifasciata in the region. Given the possibility of both natural dispersal and human-assisted transport, we treat A. trifasciata in Greece as a cryptogenic, recently expanding species.

Kalaentzis K, Bauer T, Kaitetzidou E, BIOSCAN Collective WSI, Chatzaki M, Triantafyllidis A (2026) First records and DNA barcoding of Argiope trifasciata (Forsskål, 1775) (Araneae, Araneidae) in Greece. Check List 22(5): 778-787. https://doi.org/10.15560/22.5.778