Proteomic characterization of Tityus championi venom and recombinant expression of its major neurotoxin

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  Proteomic characterization of Tityus championi venom and recombinant expression of its major neurotoxin Abstract Background:   Tityus championi is a species endemic to the southern Talamanca Mountain Range, along the border region between Costa Rica and Panama, and has been associated with severe clinical cases. Despite its medical relevance, the composition of its venom remains poorly studied. The present study aimed to characterize the proteomic composition of T. championi venom, identify its main toxin families, and recombinantly produce one of its most abundant and lethal toxins for potential use in antivenom development. Methods:   Venom composition was analyzed by tandem mass spectrometry (MS/MS), enabling the identification of venom proteins. Subsequently, one of its primary lethal toxins (Tcham27) was identified and recombinantly expressed. Results:   Proteomic analysis revealed that the most abundant family in the venom corresponded to metalloproteases, ...

Huntsman spiders of the genus Sinopoda (Araneae, Sparassidae, Heteropodinae) from the Honghe Hani and Yi Autonomous Prefecture, southwestern China, with descriptions of two new species

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Huntsman spiders of the genus Sinopoda (Araneae, Sparassidae, Heteropodinae) from the Honghe Hani and Yi Autonomous Prefecture, southwestern China, with descriptions of two new species

Abstract

Spiders of the genus Sinopoda Jäger, 1999 from Honghe Hani and Yi Autonomous Prefecture, Yunnan Province, China are studied. A total of four species are reported and illustrated of which two, Sinopoda honghe Yu & Zhong, sp. nov. and Sinopoda kuan Yu & Zhong, sp. nov., are described as new to science. The other two previously described species from this region: S. tengchongensis Fu & Zhu, 2008 and S. tumefacta Zhong, Jäger, Chen & Liu, 2019 are also illustrated. Detailed descriptions, diagnoses, illustrations and DNA barcodes of the two new species are given. A distribution map of these four species in Honghe is provided.

Zhang C, Xing Y, Zhong Y, Yu H (2026) Huntsman spiders of the genus Sinopoda (Araneae, Sparassidae, Heteropodinae) from the Honghe Hani and Yi Autonomous Prefecture, southwestern China, with descriptions of two new species. ZooKeys 1280: 301-320. https://doi.org/10.3897/zookeys.1280.183824