Scorpion Venom Peptides: Novel Therapeutic Approaches for Inflammatory and Hepatic Disorders

Posted by
  Scorpion Venom Peptides: Novel Therapeutic Approaches for Inflammatory and Hepatic Disorders Abstract Chronic hepatic disorders, such as metabolic dysfunction associated steatohepatitis (MASH), alcohol associated liver disease (ALD), and viral hepatitis (Hepatitis B Virus [HBV]/Hepatitis C Virus [HCV]), are primarily driven by persistent immune-mediated inflammation and hepatic stellate cell activation leading to fibrosis, yet conventional therapies lack tissue and molecular specificity. Scorpion venom peptides, refined through evolutionary selection, provide highly potent, target specific scaffolds capable of modulating intrahepatic inflammatory networks. Recent in vivo preclinical studies indicate that voltage gated potassium (Kv1.3) channel blocking peptides, such as BmKK2, significantly reduce macrophage activation and inhibit downstream cytokine production, effectively ameliorating diet-induced steatohepatitis and tissue scarring in murine models. Engineered hepatotropic ca...

Five new species and one new record of armored spiders (Araneae, Tetrablemmidae) from Thailand

Posted by

 


Five new species and one new record of armored spiders (Araneae, Tetrablemmidae) from Thailand

Abstract

Five new cave-dwelling species and one newly recorded litter-dwelling species belonging to the family Tetrablemmidae are described from Thailand, i.e., Ablemma erna Lehtinen, 1981 (♂♀), A. theppratan Tong & Li, sp. nov. (♂♀), A. yamae Tong & Li, sp. nov. (♂♀), Shearella khaoplu Tong & Li, sp. nov. (♂), S. thamphothisat Tong & Li, sp. nov. (♂) and Tetrablemma lorkor Tong & Li, sp. nov. (♂). Diagnoses and illustrations for all six species are given.

Shi S, Bian D, Tong Y, Li S (2026) Five new species and one new record of armored spiders (Araneae, Tetrablemmidae) from Thailand. ZooKeys 1279: 285-310. https://doi.org/10.3897/zookeys.1279.189587