Scorpion Venom Peptides: From Structural Scaffolds to Therapeutic Applications—A Focus on Antioxidant Mechanisms and Translational Perspectives

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  Scorpion Venom Peptides: From Structural Scaffolds to Therapeutic Applications—A Focus on Antioxidant Mechanisms and Translational Perspectives Abstract Scorpion venom peptides, with their stable disulfide backbone, compact structural framework, and highly selective regulation of ion channels, have long been regarded as important molecular probes in neuropharmacology. However, recent studies have revealed their potential for regulating oxidative stress, inflammation, and neuroprotection, making them a new research frontier. In this article, we focus on scorpion venom peptides as drugs, constructing an integrated knowledge framework from structural classification to clinical translation. First, scorpion venom peptides are systematically classified based on cysteine arrangement patterns and three-dimensional folding topology, and their structure–activity relationships are summarized. Based on this, the molecular mechanisms by which scorpion venom peptides regulate ion channels are ...

A review of Idiommata Ausserer, 1871 (Mygalomorphae: Barychelidae), with the description of a related new genus and new species of giant Australian brush-footed spiders

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A review of Idiommata Ausserer, 1871 (Mygalomorphae: Barychelidae), with the description of a related new genus and new species of giant Australian brush-footed spiders

Abstract

The barychelid genus Idiommata Ausserer, 1871 is reviewed: the type species Idiommata blackwalli O. Pickard-Cambridge, 1870 is diagnosed and variability of characters in males discussed. Idiommata is rediagnosed to include only I. blackwalli and I. scintillans (Rainbow & Pulleine, 1918), which lack intercheliceral peg setae. The female paralectotype of Idiommata scintillans is placed in Synothele Simon, 1908 and described as a new species, Synothele xintillans sp. nov., from South Australia. A new genus, Zidiommata gen. nov., is described for I. fusca L. Koch, 1874 (for which males are described), I. iridescens (Rainbow & Pulleine, 1918) and two new species, Z. simonmaraisi sp. nov. and Z. steveirwini sp. nov., all of which have intercheliceral pegs and are found in eastern Australia.

Raven, R.J. (2026) A review of Idiommata Ausserer, 1871 (Mygalomorphae: Barychelidae), with the description of a related new genus and new species of giant Australian brush-footed spiders. Zootaxa, 5821 (2), 151–175. https://doi.org/10.11646/zootaxa.5821.2.1