Biofactories Applied to Future Antivenom Production

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  Image Credit: By Ssiltane - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=52242648 Biofactories Applied to Future Antivenom Production Abstract Background: Accidents caused by the  Loxosceles laeta  spider constitute a health problem in South America. Envenomation can lead to severe systemic manifestations, eventually compromising the patient’s life. Most regional health authorities consider antivenom administration the basis of effective treatment in the most serious cases. The availability of spider venom is the primary bottleneck for antivenom production. Herein, we present a novel biotechnological approach, based on the expression of recombinant versions of the most relevant toxin in loxoscelism, sphingomyelinase D (SphD), in insect larvae ( Spodoptera frugiperda ).  Methods: We produced two versions of SphD: one conserving its biological activities (wtSphD) and a second alternative that was designed to be genetically detoxified (dSphD...

An eyeless new species of Monoblemma Gertsch, 1941 (Araneae: Tetrablemmidae) from Venezuela, with a new record of the single-eyed Monoblemma unicum Gertsch, 1941 from the Dominican Republic

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An eyeless new species of Monoblemma Gertsch, 1941 (Araneae: Tetrablemmidae) from Venezuela, with a new record of the single-eyed Monoblemma unicum Gertsch, 1941 from the Dominican Republic

The genus Monoblemma Gertsch, 1941 was recently revised by Martínez (2025) and currently comprises four species, mainly distributed in the Caribbean (World Spider Catalog 2026). Species of the genus exhibit remarkable variation in eye number, ranging from completely eyeless forms, such as Monoblemma becki Brignoli, 1978, to a single-eyed condition, with the eye positioned at the margin of the clypeal declivity in M. unicum Gertsch, 1941, and to four-eyed species, such as M. cambridgei (Bryant, 1940) and M. cubaense Martínez, 2025. In the original description of M. unicum, Gertsch (1941) noted that, because only a single specimen was available, the presence of one median eye might represent an abnormal condition. However, he also suggested that its median position and apparently normal development indicated that it was likely a constant feature of the species, probably resulting from the fusion of the anterior eyes present in species with two or four eyes. The discovery of a second specimen of Monoblemma unicum from the Dominican Republic exhibiting the same ocular condition confirms Gertsch’s hypothesis and supports the interpretation of the single eye as a stable, species-specific character. Additionally, a new eyeless species from Sucre, Venezuela is described based on both sexes, representing the second eyeless species in the genus. An updated distribution map and an identification key to all species of the genus are also provided.

 Martínez, L. (2026) An eyeless new species of Monoblemma Gertsch, 1941 (Araneae: Tetrablemmidae) from Venezuela, with a new record of the single-eyed Monoblemma unicum Gertsch, 1941 from the Dominican Republic. Zootaxa, 5787 (2), 394–400. https://doi.org/10.11646/zootaxa.5787.2.12