Investigating the therapeutic role of Leuculectin, a C-type lectin from Bothrops leucurus snake venom, in corneal neovascularization

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  Investigating the therapeutic role of Leuculectin, a C-type lectin from Bothrops leucurus snake venom, in corneal neovascularization Abstract Pathological corneal neovascularization remains a major therapeutic challenge due to the limited efficacy and safety of currently available antiangiogenic treatments. Although C-type lectins from snake venom possess various biological activities, their potential to modulate pathological ocular angiogenesis has not been explored. This study investigated the antiangiogenic effects of Leuculectin, a C-type lectin isolated from Bothrops leucurus venom using an experimental model of corneal neovascularization (CNV), a HUVEC (human umbilical vein endothelial cell) tube formation assay, and the chick embryo chorioallantoic membrane (CAM) assay. In the HUVEC tube formation assay, Leuculectin demonstrated strong antiangiogenic activity. In the CAM assay, Leuculectin applied at concentrations of 1.5, 2.5 and 3.5 μg/mL significantly decreased new ves...

Redescription of Nhandu chromatus Schmidt, 2004 stat. rest. and revalidation of Nhandu sylviae Sherwood, Gabriel & Brescovit, 2023 stat. rest. (Araneae: Theraphosidae)

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Redescription of Nhandu chromatus Schmidt, 2004 stat. rest. and revalidation of Nhandu sylviae Sherwood, Gabriel & Brescovit, 2023 stat. rest. (Araneae: Theraphosidae)

Abstract

Nhandu chromatus Schmidt, 2004 stat. rest. is redescribed based on the holotype male and new non-type female material, with its generic position discussed. Nhandu sylviae Sherwood, Gabriel & Brescovit, 2023 stat. rest. is restored, reversing its synonymy with Vitalius sorocabae (Mello-Leitão, 1923).

Acknowledgment: I would like to extend my sincere thanks to Danni Sherwood for providing the complete manuscript.

Sherwood, Danniella & Peñaherrera-R, Pedro & Brescovit, Antonio & Lucas, Sylvia. (2026). Redescription of Nhandu chromatus Schmidt, 2004 stat. rest. and revalidation of Nhandu sylviae Sherwood, Gabriel & Brescovit, 2023 stat. rest. (Araneae: Theraphosidae). Arachnology. 20. 519-526.