Venom induced pressure elevation reversible syndrome: a severe pediatric rattlesnake envenomation, evidence for conservative management, and call for naming the syndromeVenom induced pressure elevation reversible syndrome: a severe pediatric rattlesnake envenomation, evidence for conservative management, and call for naming the syndrome

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  Venom induced pressure elevation reversible syndrome: a severe pediatric rattlesnake envenomation, evidence for conservative management, and call for naming the syndromeVenom induced pressure elevation reversible syndrome: a severe pediatric rattlesnake envenomation, evidence for conservative management, and call for naming the syndrome Abstract Introduction : Rattlesnake envenomation frequently mimics traumatic compartment syndrome, as both are characterized by severe pain, swelling, and elevated compartment pressures. Unlike traumatic compartment syndrome there have been no documented cases of ischemic limb injury after envenomated patients have received antivenom. Furthermore, there is experimental evidence that fasciotomy worsens myonecrosis. This has led medical toxicologists and surgical guidelines to shift from liberally recommending fasciotomy to near universal recommendation of antivenom alone. Despite this, fasciotomies continue to be recommended and performed on rattle...

Preliminary evaluation of a monovalent antivenom targeting Cerastes cerastes envenomation in North Africa: feasibility and specificity assessment

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Preliminary evaluation of a monovalent antivenom targeting Cerastes cerastes envenomation in North Africa: feasibility and specificity assessment

Abstract

In 2017, the World Health Organization (WHO) recognized snakebite envenomation as a neglected disease yet the therapeutic effectiveness efficacy of available antivenoms remains insufficiently explored. This study offers a detailed analysis of Cerastes cerastes venom, focusing its toxicological properties and the development of specific targeted neutralizing antibodies. Through rigorous quality control and comprehensive efficacy testing, the antivenom demonstrated significant neutralizing activity against critical venom components, including hemorrhagic, edema-forming, and myotoxic effects while also mitigating tissue damage. Histological investigations further corroborated the antivenom’s protective capacity. These findings not only underscore the potential of the developed antivenom for clinical use but also provide essential insights for advancing antivenom production, refining its specificity, and enhancing its therapeutic efficacy in managing snake envenomations.

Mesmoudi, N., Chakir, S., Ammouch, K., Chahir, R., Aassila, H., Moustaghfir, A., Karkouri, M., & Oukkache, N. (2026). Preliminary evaluation of a monovalent antivenom targeting Cerastes cerastes envenomation in North Africa: Feasibility and specificity assessment. Frontiers in Pharmacology, 17, 1719611. https://doi.org/10.3389/fphar.2026.1719611