Can Scorpion Venom Peptides Be Safely Used in Cardiovascular Therapy: A Systematic Review

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  Can Scorpion Venom Peptides Be Safely Used in Cardiovascular Therapy: A Systematic Review Abstract Scorpion venom contains numerous bioactive peptides with potent cardiovascular effects, including bradykinin-potentiating peptides (BPPs), ion channel modulators, and cardioprotective molecules. These peptides show promise for conditions such as hypertension, cardiac injury, and arrhythmias. However, concerns regarding toxicity, immunogenicity, and off-target actions have limited their clinical development. This systematic review evaluates the therapeutic potential and safety of scorpion venom peptides for cardiovascular applications. A systematic search of PubMed, Scopus, Google Scholar, and Semantic Scholar identified 1,141 articles. Screening of 463 abstracts and full-text review of 446 eligible studies resulted in 17 publications meeting the inclusion criteria. Extracted data included mechanisms, efficacy, toxicity, and translational challenges. BPPs consistently demonstrated AC...

Ghost sighting: first Southeast Asian record of the ghost spider family Anyphaenidae, describing a new Rathalos species from Java, Indonesia

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Ghost sighting: first Southeast Asian record of the ghost spider family Anyphaenidae, describing a new Rathalos species from Java, Indonesia

ABSTRACT

A new species of bamboo-associated ghost spider, Rathalos inagami Dhiya’ulhaq & Dwikelana sp. nov., is described from Java, Indonesia, based on male and female specimens. The species is diagnosed by distinct genitalic characters, including a four-lobed median apophysis in males and a wide triangular epigynal plate with strongly S-shaped copulatory ducts in females. This constitutes the first record of the family Anyphaenidae and the genus Rathalos from Southeast Asia, thereby extending the known distribution of the group.