Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides

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  Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides Abstract Purpose Bradykinin-potentiating peptides (BPPs), found in snake venom, are known to modulate cardiovascular functions, but their susceptibility to enzymatic degradation remains poorly understood. Methods Models were generated using AlphaFold-Colab for five small BPPs (< 9 amino acids) that did not have experimentally solved structures, and those BPPs which had reliable predictions of structure (pLDDT > 80) were used for docking studies. Protein-peptide docking experiments were done using HADDOCK for studying the interaction between wild-type (WT) and mutant serratiopeptidase with BPPs. After selecting the best complex, simulation of the complex was done using molecular dynamics (MD) simulations for 100 ns and binding energy determination using MM/PBSA analysis. For checking the mechanical stability of the protein-peptide complexes...

On nine species of the genus Bowie (Araneae: Ctenidae) from China and Malaysia

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On nine species of the genus Bowie (Araneae: Ctenidae) from China and Malaysia

Abstract

Nine species of the genus Bowie Jäger, 2022 are recorded from China and Malaysia, including seven new species described here. Five species are reported from Yunnan, China: Bowie achang Shang, Zhang & Wang, sp. nov. (male, female), B. dai Shang, Zhang & Wang, sp. nov. (male, female), B. lahu Shang, Zhang & Wang, sp. nov. (male), B. nangunhe Yang, Zhang & Wang, sp. nov. (male, female) and B. wa Yang, Zhang & Wang, sp. nov. (male, female). Additionally, B. tujia Shang, Zhang & Wang, sp. nov. (male) is described from Guizhou, China, and B. weiweii Shang, Zhang & Wang, sp. nov. (male, female) from Sabah, Malaysia. The previously unknown sexes of B. lishuqiang Jäger, 2012 (male, from Chongqing, Sichuan and Guangxi of China) and B. mengla Yao & Li, 2022 (female, from Yunnan of China) are described here for the first time. Photos of habitus, copulatory organs and a distribution map for all species are provided.

Shang, J.-X., Tian, Y., Zhang, Z.-S., Wang, L.-Y. & Yang, Z.-Z. (2026) On nine species of the genus Bowie (Araneae: Ctenidae) from China and Malaysia. Zootaxa, 5760 (1), 57–74. https://doi.org/10.11646/zootaxa.5760.1.2